1-[2,5-Bis(trifluoromethyl)phenyl]-2-chloroethanone | 1214332-08-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2,5-Bis(trifluoromethyl)phenyl]-2-chloroethanone
• CAS: 1214332-08-7
• 化学式: C₁₀H₅ClF₆O
• 分子量: 290.59
• InChiKey: NGUKSAJRBAAIJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES<br/>[FR] PROCEDE DE PRODUCTION DE DERIVES DE 2-ALCOXYACETOPHENONE TRIFLUOROMETHYLE-SUBSTITUEE
  申请人：CENTRAL GLASS CO LTD

  公开号：WO2004014887A1

  公开（公告）日：2004-02-19

  A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether.

  生产溴代缩醛（化学式3）的过程包括：（a）在烷基二醇存在下，用Br2对三氟甲基取代的乙酰苯甲酮进行溴化。可以通过以下步骤制备三氟甲基取代的2-烷氧基乙酰苯甲酮衍生物（化学式9）：（b）将溴代缩醛与金属烷氧化物反应，将溴代缩醛转化为醚；（c）在酸催化剂存在下水解醚，从而从醚中去除缩醛基，从而制备2-烷氧基乙酰苯甲酮衍生物。或者，可以通过以下步骤制备2-烷氧基乙酰苯甲酮：（a）将三氟甲基取代的苯甲酰卤与缩醛化试剂反应，将苯甲酰卤转化为缩醛；（b）将缩醛与金属烷氧化物反应，将缩醛转化为醚；（c）在酸催化剂存在下水解醚，从而从醚中去除缩醛基。
• Process for producing trifluoromethyl- substituted 2- alkoxyacetophenone derivatives
  申请人：Ishii Akihiro

  公开号：US20050171363A1

  公开（公告）日：2005-08-04

  A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br 2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether.

  生产溴化缩醛（由式 3 表示）的工艺包括 (a) 用 Br 2 溴化三氟甲基取代的苯乙酮。可选择通过以下方法生产三氟甲基取代的 2-烷氧基苯乙酮衍生物（由式 9 表示）：(b) 使溴化缩醛与金属氧化烷反应，从而将溴化缩醛转化为醚；(c) 在酸催化剂存在下水解醚，从醚中除去缩醛基团，从而生产 2-烷氧基苯乙酮衍生物。或者，2-烷氧基苯乙酮可以通过以下方法制得：(a) 使三氟甲基取代的苯酰卤与缩醛剂反应，从而将苯酰卤转化为缩醛；(b) 使缩醛与金属烷氧基反应，从而将缩醛转化为醚；(c) 在酸催化剂存在下水解醚，以除去醚中的缩醛基团。
• PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES
  申请人：Central Glass Company, Limited

  公开号：EP1546126A1

  公开（公告）日：2005-06-29
• Process for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivatives
  申请人：Ishii Akihiro

  公开号：US20060128976A1

  公开（公告）日：2006-06-15

  A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br 2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether.
• US7053248B2
  申请人：——

  公开号：US7053248B2

  公开（公告）日：2006-05-30