摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

Ethyl 2-[6-(4-methoxyphenoxy)-5,7-dimethyl-1-benzofuran-3-yl]acetate | 463927-58-4

中文名称
——
中文别名
——
英文名称
Ethyl 2-[6-(4-methoxyphenoxy)-5,7-dimethyl-1-benzofuran-3-yl]acetate
英文别名
——
Ethyl 2-[6-(4-methoxyphenoxy)-5,7-dimethyl-1-benzofuran-3-yl]acetate化学式
CAS
463927-58-4
化学式
C21H22O5
mdl
——
分子量
354.403
InChiKey
QOAUHDBFKFMQOW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.7
  • 重原子数:
    26
  • 可旋转键数:
    7
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.29
  • 拓扑面积:
    57.9
  • 氢给体数:
    0
  • 氢受体数:
    5

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    Ethyl 2-[6-(4-methoxyphenoxy)-5,7-dimethyl-1-benzofuran-3-yl]acetatesodium hydroxide三氯化铝乙硫醇 作用下, 以 二氯甲烷 为溶剂, 反应 6.0h, 生成 2-[6-(4-Hydroxyphenoxy)-5,7-dimethyl-1-benzofuran-3-yl]acetic acid
    参考文献:
    名称:
    Novel heterocyclic thyromimetics. Part 2
    摘要:
    Novel heterocyclic thyromimetics are presented carrying carboxy-substituted benzofurans or sulfur containing heterocycles, as replacements for the amino acid side chain of T3. Potent agonists were identified in both series. SAR trends are examined and found to be mostly consistent with previously published thyromimetics. The lack of isoform selectivity demonstrated with isoform-selective transient THR transfection assays has been confirmed by corresponding in vivo studies. (C) 2007 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmcl.2007.04.085
  • 作为产物:
    参考文献:
    名称:
    Novel heterocyclic thyromimetics. Part 2
    摘要:
    Novel heterocyclic thyromimetics are presented carrying carboxy-substituted benzofurans or sulfur containing heterocycles, as replacements for the amino acid side chain of T3. Potent agonists were identified in both series. SAR trends are examined and found to be mostly consistent with previously published thyromimetics. The lack of isoform selectivity demonstrated with isoform-selective transient THR transfection assays has been confirmed by corresponding in vivo studies. (C) 2007 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmcl.2007.04.085
点击查看最新优质反应信息

文献信息

  • Benzofuran derivatives
    申请人:——
    公开号:US20040220415A1
    公开(公告)日:2004-11-04
    The invention relates to novel benzofuran derivatives, to processes for preparing them and to their uses in medicaments.
    本发明涉及新型苯并呋喃衍生物,其制备方法以及在药物中的应用。
  • US7015246B2
    申请人:——
    公开号:US7015246B2
    公开(公告)日:2006-03-21
  • Novel heterocyclic thyromimetics. Part 2
    作者:Helmut Haning、Ulrich Mueller、Gunter Schmidt、Carsten Schmeck、Verena Voehringer、Axel Kretschmer、Hilmar Bischoff
    DOI:10.1016/j.bmcl.2007.04.085
    日期:2007.7
    Novel heterocyclic thyromimetics are presented carrying carboxy-substituted benzofurans or sulfur containing heterocycles, as replacements for the amino acid side chain of T3. Potent agonists were identified in both series. SAR trends are examined and found to be mostly consistent with previously published thyromimetics. The lack of isoform selectivity demonstrated with isoform-selective transient THR transfection assays has been confirmed by corresponding in vivo studies. (C) 2007 Elsevier Ltd. All rights reserved.
查看更多