2-Pyridinamine, 6-methyl-5-(8-quinolinyl)- | 1258618-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Pyridinamine, 6-methyl-5-(8-quinolinyl)-
• 英文别名: 6-methyl-5-quinolin-8-ylpyridin-2-amine
• CAS: 1258618-27-7
• 化学式: C₁₅H₁₃N₃
• mdl: MFCD18085167
• 分子量: 235.28
• InChiKey: GJLVRKZZRKPWFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 5-HETEROARYL-PYRIDIN-2-AMINE COMPOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS
  申请人：Domain Therapeutics

  公开号：US20220298135A1

  公开（公告）日：2022-09-22

  The present invention relates to novel aminopyridine derivatives of the general formula (I) and pharmaceutical compositions comprising these compounds, as well as their therapeutic use, particularly as neuropeptide FF (NPFF) receptor antagonists, including, e.g., for the treatment or prevention of pain, opioid-induced hyperalgesia, or addiction.
• [EN] 5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS DE 5-HÉTÉROARYL-PYRIDIN-2-AMINE EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DU NEUROPEPTIDE FF
  申请人：DOMAIN THERAPEUTICS

  公开号：WO2021023813A1

  公开（公告）日：2021-02-11

  The present invention relates to novel aminopyridine derivatives of the general formula (I) and pharmaceutical compositions comprising these compounds, as well as their therapeutic use, particularly as neuropeptide FF (NPFF) receptor antagonists, including, e.g., for the treatment or prevention of pain, opioid-induced hyperalgesia, or addiction.