2-Hydrazinyl-5,6,7,8-tetrahydroquinoline | 937677-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Hydrazinyl-5,6,7,8-tetrahydroquinoline
• 英文别名: 5,6,7,8-tetrahydroquinolin-2-ylhydrazine
• CAS: 937677-75-3
• 化学式: C₉H₁₃N₃
• mdl: MFCD09034994
• 分子量: 163.22
• InChiKey: ZSADQFQOENPNDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.444
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PROCESS FOR THE DIASTEREOSELECTIVE PREPARATION OF RUTHENIUM COMPLEXES<br/>[FR] PROCÉDÉ DE PRÉPARATION DIASTÉRÉOSÉLECTIVE DE COMPLEXES DE RUTHÉNIUM
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014166777A1

  公开（公告）日：2014-10-16

  The present invention relates to a process for the preparation of a compound of formula (I), wherein X is -CH2-, -CH2-CH2-, -CH2-CH2-CH2- or -CH2-CH2-CH2-CH2-; Y1 is -CH2-; -CH2-CH2- or -NH-; Y2 is NHR7 or SH; wherein R7 is hydrogen, C1-C4alkyl or phenyl; R-1 and R2, independently from each other, represent aliphatic or aromatic groups; R3 and R4, independently from each other, represent aliphatic or aromatic groups; R5 and R6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI2(R8)n]m (II), wherein n is 1 and m is > 1 which represents a polymeric structure if R8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if R8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 1 12°C to 165°C with a compound of formula (III), wherein R5, R6, Y1 and Y2 are as defined under formula I, and a phosphane of formula IV R3R4P-X-PR1 R2 (iv), wherein R1, R2, R3, R4 and X are as defined under formula I.

  本发明涉及一种制备式（I）化合物的方法，其中X为-CH2-，-CH2-CH2-，-CH2-CH2-CH2-或-CH2-CH2-CH2-CH2-；Y1为-CH2-，-CH2-CH2-或-NH-；Y2为NHR7或SH；其中R7为氢、C1-C4烷基或苯基；R-1和R2，各自独立地表示脂肪族或芳香族基团；R3和R4，各自独立地表示脂肪族或芳香族基团；R5和R6分别为氢或与它们所连接的碳原子一起表示苯环；该方法包括将式II [RuCI2（R8）n]m（II）的化合物与式III的化合物在惰性溶剂的存在下反应，其中R5，R6，Y1和Y2在式I下定义，并与式IV的膦化合物反应，其中R1，R2，R3，R4和X在式I下定义，其中n为1，m>1，如果R8是含有两个烯烃或炔烃官能团协同配位到金属的分子，则代表聚合结构；如果R8是氮、氧或硫含有分子，则n为4，m为1，其中所述的氮、氧或硫配位到金属上。
• PROCESS FOR THE DIASTEREOSELECTIVE PREPARATION OF RUTHENIUM COMPLEXES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US20160046658A1

  公开（公告）日：2016-02-18

  The present invention relates to a process for the preparation of a compound of formula (I), wherein X is —CH 2 —, —CH 2 —CH 2 —, —CH 2 —CH 2 —CH 2 — or —CH 2 —CH 2 —CH 2 —CH 2 —; Y 1 is —CH 2 —; —CH2—CH 2 — or —NH—; Y 2 is NHR 7 , or SH; wherein R 7 is hydrogen, C 1 -C 4 alkyl or phenyl; R— 1 and R 2 , independently from each other, represent aliphatic or aromatic groups; R 3 and R 4 , independently from each other, represent aliphatic or aromatic groups; R 5 and R 6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI 2 (R 8 )n]m (II), wherein n is 1 and m is >1 which represents a polymeric structure if R 8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if R 8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 112° C. to 165° C. with a compound of formula (III), wherein R 5 , R 6 , Y 1 and Y 2 are as defmed under formula I, and a phosphane of formula IV R3R4P—X—PR 1 R 2 (iv), wherein R 1 , R 2 , R 3 , R 4 and X are as defined under formula I.
• US9303054B2
  申请人：——

  公开号：US9303054B2

  公开（公告）日：2016-04-05