(E)-6-Methyl-5-decen-2-one | 140926-70-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-6-Methyl-5-decen-2-one
• 英文别名: 6-methyl-2-oxo-5-decene；6-methyl-5-decen-2-one；6-Methyl-5(6)-decen-2-one；(E)-6-methyldec-5-en-2-one
• CAS: 140926-70-1
• 化学式: C₁₁H₂₀O
• 分子量: 168.279
• InChiKey: JXFUWSXVBVBOGF-CSKARUKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  乙烯基溴化镁 、 (E)-6-Methyl-5-decen-2-one 生成 3,7-dimethyl-1,6-undecadien-3-ol
  参考文献：
  名称：

  Methylene dioxyphenyl ethers

  摘要：

  1,2-二甲氧基苯的烷基或烯基醚，可通过干扰昆虫激素系统来对抗昆虫。

  公开号：

  US04011335A1
• 作为产物：
  描述：

  三甲基铝 、 丁烯酮 、 1-己炔 生成 (E)-6-Methyl-5-decen-2-one
  参考文献：
  名称：

  Transmetalation reactions of alkenylalanes: copper-catalyzed conjugate addition to enones

  摘要：

  An improved synthetic strategy for the in situ preparation of vinyl cuprates from alkynes is presented and used for the stereospecific synthesis of di-, tri-, and tetrasubstituted olefin& Hydroalumination or Cp2ZrCl2-catalyzed carboalumination of alkynes, followed by in situ transmetalation to bis-alkynyl-copper complex [(C4H9C = C)2CuCN]Li2 and addition of enones, led to the isolation of 1,4-addition products in high yields. Stoichiometric or catalytic amounts of copper complex gave similar results. However, in the presence of less than 10 mol % of Cu(I) complex, side products were formed and a significant drop in the yield of the desired conjugate addition product was observed. An ate-transfer mechanism is postulated for the rapid exchange of vinyl ligands from AI(III) to Cu(I) at low temperatures.

  DOI：

  10.1021/jo00037a040

文献信息

• Synthesis of dioxabicyclo[3.2.1]octanes and oxepanes
  申请人：Ortho Pharmaceutical Corporation

  公开号：US04276216A1

  公开（公告）日：1981-06-30

  The synthesis of C-4 alkyl analogs of racemic (1RS,4SR,5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyc lo[3.2.1]octane-1-acetic acid and the corresponding (1RS,4RS,5RS)- derivative is described. The dioxabicyclo[3.2.1]octanes are useful as contragestational agents.

  描述了C-4烷基类似物的合成，其为racemic(1RS,4SR,5RS)-4-(4,8-二甲基-5-羟基-7-壬烯基)-4-甲基-3,8-二氧杂双环[3.2.1]辛烷-1-乙酸和相应的(1RS,4RS,5RS)-衍生物。这些二氧杂双环[3.2.1]辛烷对于避孕有用。
• Synthesis of dioxabicyclo(3.2.1)octanes and oxepanes
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0045631A2

  公开（公告）日：1982-02-10

  The synthesis of C-4 alkyl analogs of racemic (1 RS,4SR,5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyclo[3.2.1]octane-1-acetic acid and the corresponding (1RS,4RS,5RS)- derivative is described. The dioxabicyclo[3.2.1]octanes are useful as contragestational agents. The intermediate oxepane analogs are useful as intermediates in the preparation of the contragestational agent zoapatanol.

  介绍了外消旋(1RS,4SR,5RS)-4-(4,8-二甲基-5-羟基-7-壬烯基)-4-甲基-3,8-二氧杂环[3.2.1]辛烷-1-乙酸的 C-4 烷基类似物和相应的(1RS,4RS,5RS)-衍生物的合成。二氧杂环[3.2.1]辛烷可用作避孕药。中间体氧杂环庚烷类似物可用作制备避孕药佐帕他醇的中间体。
• Synthesis of dioxabicyclo[3.2.1]octanes
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0175427A1

  公开（公告）日：1986-03-26

  The synthesis of C-4 alkyl analogs of racemic (1 RS,4RS,-5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8--dioxabicyclo[3.2.1 ]octane-1-acetic acid and the corresponding (1RS,4RS,5RS)-derivative is described. The dioxabicyclo-[3.2.1]octanes are useful as contragestational agents.

  本文介绍了外消旋(1RS,4RS,-5RS)-4-(4,8-二甲基-5-羟基-7-壬烯基)-4-甲基-3,8-二氧杂环双环[3.2.1 ]辛烷-1-乙酸的 C-4 烷基类似物以及相应的(1RS,4RS,5RS)衍生物的合成。二氧双环[3.2.1]辛烷可用作避孕药。
• COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION
  申请人：Ishida Kenya

  公开号：US20110117147A1

  公开（公告）日：2011-05-19

  The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may have one or more substituents, in which A and B are not hydrogen atoms simultaneously, and the total number of carbon atoms in A and B is in the range of 6 to 18; and Formulae (2) to (4) wherein R1, R2, and R3 each represent a residue of an alcohol selected from 1-menthol, 1-isopulegol, 3-(1-menthoxy)propan-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propan-1,2-diol and para-menthan-3,8-diol), and R4 represents a residue of a branched or straight-chain, cyclic or linear, or saturated or unsaturated alcohol having 6 to 18 carbon atoms that may have one or more aromatic rings that may have a condensed ring and substituent groups such as hydroxyl and ether groups; and R6 represents a hydrocarbon group having 11 to 19 carbon atoms that may be branched and contain one or more unsaturated bonds. The invention also relates to a sensory stimulation agent composition comprising the cooling sensation agent composition; a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition or the sensory stimulation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent composition or the sensory stimulation agent composition; and new compounds.
• US4011335A
  申请人：——

  公开号：US4011335A

  公开（公告）日：1977-03-08