Quinoline-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Quinoline-4-carboxylate
• 化学式: C10H6NO2-
• 分子量: 172.16
• InChiKey: VQMSRUREDGBWKT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  A 、 水 、 Quinoline-4-carboxylate 生成 2-Oxo-1,2-dihydroquinoline-4-carboxylate 、 AH₂
  参考文献：
  名称：

  Microbial Metabolism of Quinoline and Related Compounds. XV. Quinoline-4-carboxylic acid Oxidoreductase fromAgrobacterium spec.1B:A Molybdenum-Containing Enzyme

  摘要：

  The quinoline-4-carboxylic acid oxido-reductase from Agrobacterium spec.1B was purified 84-fold to apparent homogeneity with 15% recovery, using ammonium sulphate precipitation, heat precipitation, hydrophobic interaction, anion exchange- and gel chromatography. The molecular mass of the native enzyme was estimated to be 320 kDa by gel filtration. SDS-polyacrylamide gel electrophoresis of the enzyme revealed three protein bands corresponding to 85, 35 and 21 kDa. Per molecule the enzyme contains 8 atoms Of iron, 8 atoms of acid-labile sulphur, 2 atoms of molybdenum, 2 molecules of FAD and as molybdenum. cofactor, molybdopterin cytosine dinucleotide.Besides quinoline-4-carboxylic acid the enzyme also catalysed the conversion of quinoline, 4-chloroquinoline and 4-methylquinoline to the corresponding 2-oxo-1,2-dihydroderivatives. Cyanide, methanol, 4-chloromercuribenzoate and acriflavin were effective inhibitors.

  DOI：

  10.1515/bchm3.1992.373.2.699