1-furan-2-ylmethyl-5-(4-methoxyphenyl)-4-phenyl-1,3-dihydro-imidazol-2-one | 1006593-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-furan-2-ylmethyl-5-(4-methoxyphenyl)-4-phenyl-1,3-dihydro-imidazol-2-one
• 英文别名: 3-(furan-2-ylmethyl)-4-(4-methoxyphenyl)-5-phenyl-1H-imidazol-2-one
• CAS: 1006593-34-5
• 化学式: C₂₁H₁₈N₂O₃
• 分子量: 346.386
• InChiKey: WTOHHLIWWRKOCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  furan-2-ylmethyl-[1-(4-methoxy-phenyl)-2-oxo-2-phenyl-ethyl]-carbamic acid benzyl ester 在 乙酸铵 作用下， 以 溶剂黄146 为溶剂， 反应 16.0h， 生成 1-furan-2-ylmethyl-5-(4-methoxyphenyl)-4-phenyl-1,3-dihydro-imidazol-2-one
  参考文献：
  名称：

  Palladium-Catalyzed Carbonylative Cross-Coupling with Imines:  A Multicomponent Synthesis of Imidazolones

  摘要：

  [GRAPHICS]The palladium-catalyzed coupling of imines, chloroformates, organotin reagents, and carbon monoxide leads to the one-pot formation of ketocarbamates in good yields. These products can further be converted to highly substituted imidazolones via a cyclocondensation reaction. Overall, this methodology provides an alternative approach to imidazolones from five simple and readily available building blocks via a one-pot, multicomponent process.

  DOI：

  10.1021/jo701875b

文献信息

• Palladium-Catalyzed Carbonylative Cross-Coupling with Imines:  A Multicomponent Synthesis of Imidazolones
  作者：Ali R. Siamaki、Daniel A. Black、Bruce A. Arndtsen

  DOI：10.1021/jo701875b

  日期：2008.2.1

  [GRAPHICS]The palladium-catalyzed coupling of imines, chloroformates, organotin reagents, and carbon monoxide leads to the one-pot formation of ketocarbamates in good yields. These products can further be converted to highly substituted imidazolones via a cyclocondensation reaction. Overall, this methodology provides an alternative approach to imidazolones from five simple and readily available building blocks via a one-pot, multicomponent process.