2-[(1E)-1-aza-2-(4-methoxyphenyl)vinyl]-4-(7-nitro-9-chloroacridin-2-yl)-1,3-thiazole | 1138336-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[(1E)-1-aza-2-(4-methoxyphenyl)vinyl]-4-(7-nitro-9-chloroacridin-2-yl)-1,3-thiazole
• 英文别名: (E)-N-[4-(9-chloro-7-nitroacridin-2-yl)-1,3-thiazol-2-yl]-1-(4-methoxyphenyl)methanimine
• CAS: 1138336-79-4
• 化学式: C₂₄H₁₅ClN₄O₃S
• 分子量: 474.927
• InChiKey: JJCFPKMTKOUFOX-RPPGKUMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-((4-[2-((1E)-1-aza-2-(4-methoxyphenyl)vinyl)-1,3-thiazol-4-yl]-phenyl)amino)-5-nitrobenzoic acid 在 三氯氧磷 作用下， 以39%的产率得到2-[(1E)-1-aza-2-(4-methoxyphenyl)vinyl]-4-(7-nitro-9-chloroacridin-2-yl)-1,3-thiazole
  参考文献：
  名称：

  Synthesis, Characterization, and Biological Activity of Some New Benzoic Acid and Thiazoloacridine Derivatives

  摘要：

  A series of acridine derivatives 5have been synthesized by cylization of benzoic acid derivatives 4using POCl3. Compounds 4 were synthesized by Ullamnn Condensation of bromo derivatives 2 and substituted anthranilic acid, respectively, which in turn have been prepared from the Schiff bases of 4-aryl-2-amino thiazole 1 and substituted aldehydes. Biological activities of all the compounds have been studied using gram positive and gram negative bacteria and their anti-fungal activity using fungal species Aspergillus Parasiticus and Sclerotium Rolfsii. All structures of the newly synthesized heterocyclic compounds were established based on elemental analyses, IR, H-1 NMR, C-13 NMR, and mass spectra.

  DOI：

  10.1080/10426500701852687

文献信息

• Synthesis, Characterization, and Biological Activity of Some New Benzoic Acid and Thiazoloacridine Derivatives
  作者：Nilav A. Patel、Sandip C. Surti、R. G. Patel、M. P. Patel

  DOI：10.1080/10426500701852687

  日期：2008.8.4

  A series of acridine derivatives 5have been synthesized by cylization of benzoic acid derivatives 4using POCl3. Compounds 4 were synthesized by Ullamnn Condensation of bromo derivatives 2 and substituted anthranilic acid, respectively, which in turn have been prepared from the Schiff bases of 4-aryl-2-amino thiazole 1 and substituted aldehydes. Biological activities of all the compounds have been studied using gram positive and gram negative bacteria and their anti-fungal activity using fungal species Aspergillus Parasiticus and Sclerotium Rolfsii. All structures of the newly synthesized heterocyclic compounds were established based on elemental analyses, IR, H-1 NMR, C-13 NMR, and mass spectra.