Synthesis and cytotoxicity of methyl-and methoxy-substituted metal 8-quinolinethiolates
作者:E. Lukevics、D. Zaruma、J. Ashaks、I. Shestakova、I. Domracheva、A. Gulbe、V. Bridane
DOI:10.1007/s10593-008-0075-8
日期:2008.5
It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity.