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Antimony(3+);6-methoxyquinoline-8-thiolate | 47813-82-1

中文名称
——
中文别名
——
英文名称
Antimony(3+);6-methoxyquinoline-8-thiolate
英文别名
——
Antimony(3+);6-methoxyquinoline-8-thiolate化学式
CAS
47813-82-1
化学式
C30H24N3O3S3Sb
mdl
——
分子量
692.487
InChiKey
WCHRTIHGOAKCGP-UHFFFAOYSA-K
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    6.07
  • 重原子数:
    40
  • 可旋转键数:
    3
  • 环数:
    6.0
  • sp3杂化的碳原子比例:
    0.1
  • 拓扑面积:
    69.4
  • 氢给体数:
    0
  • 氢受体数:
    9

反应信息

  • 作为产物:
    描述:
    6-methoxy-8-quinolinethiolate hydrochloride 在 K(SbO)C4H4O6*0.5H2O 作用下, 以 乙醇 为溶剂, 生成 Antimony(3+);6-methoxyquinoline-8-thiolate
    参考文献:
    名称:
    Synthesis and cytotoxicity of methyl-and methoxy-substituted metal 8-quinolinethiolates
    摘要:
    It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity.
    DOI:
    10.1007/s10593-008-0075-8
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文献信息

  • Synthesis and cytotoxicity of methyl-and methoxy-substituted metal 8-quinolinethiolates
    作者:E. Lukevics、D. Zaruma、J. Ashaks、I. Shestakova、I. Domracheva、A. Gulbe、V. Bridane
    DOI:10.1007/s10593-008-0075-8
    日期:2008.5
    It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity.
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