(E,E)-N-(5-benzylsulfanyl-1,3,4-thiadiazol-2-yl)-1,3-bis(4-chlorophenyl)prop-2-en-1-imine | 1075247-23-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E,E)-N-(5-benzylsulfanyl-1,3,4-thiadiazol-2-yl)-1,3-bis(4-chlorophenyl)prop-2-en-1-imine
• CAS: 1075247-23-2
• 化学式: C₂₄H₁₇Cl₂N₃S₂
• 分子量: 482.457
• InChiKey: OBOXZGBOMSAHCI-KLIPQIDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  91.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-{[1,3-bis(4-chlorophenyl)-prop-2-en-1-ylidene]amino}-1,3,4-thiadiazole-2-thiol 、 氯化苄 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 以39%的产率得到(E,E)-N-(5-benzylsulfanyl-1,3,4-thiadiazol-2-yl)-1,3-bis(4-chlorophenyl)prop-2-en-1-imine
  参考文献：
  名称：

  Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives

  摘要：

  A number of new imine derivatives of 5-amino-1, 3, 4-thiadiazole-2-thiol have been synthesized, and their anti-depressant activity was tested using imipramine as reference drug. Two compounds namely 5-{[1-(4-chlorophenyl)-3-(4-methoxy-phenyl)prop-2-en-1-ylidene]-amino}-5-benzylthio-1, 3, 4-thiadiazole 4i(b) and 5-{[1-(4-chlorophenyl)-3-(4-dimethyl-aminophenyl)-prop-2-en-1-ylidene]amino}-5-benzylthio-1,3,4-thiadiazole 4i(c) have shown significant anti-depressant activity, which decreased immobility time by 77.99% and 76.26% compared to the standard imipramine (82%). All the compounds in the series have passed neurotoxicity tests. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.07.056

文献信息

• Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives
  作者：Mohammad Yusuf、Riaz A. Khan、Bahar Ahmed

  DOI：10.1016/j.bmc.2008.07.056

  日期：2008.9

  A number of new imine derivatives of 5-amino-1, 3, 4-thiadiazole-2-thiol have been synthesized, and their anti-depressant activity was tested using imipramine as reference drug. Two compounds namely 5-[1-(4-chlorophenyl)-3-(4-methoxy-phenyl)prop-2-en-1-ylidene]-amino}-5-benzylthio-1, 3, 4-thiadiazole 4i(b) and 5-[1-(4-chlorophenyl)-3-(4-dimethyl-aminophenyl)-prop-2-en-1-ylidene]amino}-5-benzylthio-1,3,4-thiadiazole 4i(c) have shown significant anti-depressant activity, which decreased immobility time by 77.99% and 76.26% compared to the standard imipramine (82%). All the compounds in the series have passed neurotoxicity tests. (C) 2008 Elsevier Ltd. All rights reserved.