丁烷,1-甲氧基-2-甲基-,(S)- | 1565-78-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 丁烷,1-甲氧基-2-甲基-,(S)-
• 英文名称: (S)-1-methoxy-2-methyl-butane
• 英文别名: methyl-((S)-2-methyl-butyl)-ether；Methyl-((S)-2-methyl-butyl)-aether；(+)(S)-1-Methoxy-2-methyl-butan；Methyl-d-amylaether；(S)-Methyl-(2-methyl-butyl)-aether；(+)-(S)-1-Methoxy-2-methyl-butan；(S)-1-methoxy-2-methyl-butane；(2S)-1-methoxy-2-methylbutane
• CAS: 1565-78-2
• 化学式: C₆H₁₄O
• 分子量: 102.177
• InChiKey: XGLHRCWEOMNVKS-LURJTMIESA-N

物化性质

• 沸点：
  90 °C
• 密度：
  0.753 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Bis-<(S)-2-Methyl-butoxy>-methan 在 二异丁基氢化铝 作用下， 生成 丁烷,1-甲氧基-2-甲基-,(S)-
  参考文献：
  名称：

  Salvadori,P.; Lardicci,L., Gazzetta Chimica Italiana, 1964, vol. 94, p. 1205 - 1220

  摘要：

  DOI：

文献信息

• [EN] TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION<br/>[FR] DÉRIVÉS D'INDOLES TÉTRACYCLIQUES POUR LE TRAITEMENT D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE C
  申请人：MERCK SHARP & DOHME

  公开号：WO2012041014A1

  公开（公告）日：2012-04-05

  Tetracyclic indole derivatives of formula (I), pharmaceutically acceptable salts and the pharmaceutical compositions thereof are provided, wherein A, A', G, R1, R15, U, V, V, W, W, X, X', Y, Y' are as defined in the invention. Use of these derivatives for treating hepatitis C virus (HCV) infection is also provided.

  提供了公式（I）的四环吲哚衍生物、药用盐及其药物组合物，其中A、A'、G、R1、R15、U、V、V、W、W、X、X'、Y、Y'如本发明所定义。还提供了利用这些衍生物治疗丙型肝炎病毒（HCV）感染的方法。
• Fluorinated 2-arylbenzo heterocyclic compound with high affinity to A beta 946; plaques and containing chiral side chain substituent, and preparation method and usage thereof
  申请人：BEIJING ZHIBO BIO-MEDICAL TECHNOLOGY CO., LTD

  公开号：US20160207910A1

  公开（公告）日：2016-07-21

  A fluorinated 2-arylbenzo heterocyclic compound with high affinity to Aβ plaques and containing a chiral side chain substituent, has a general formula (I) as follows: wherein X is N; Y is S or O; Z is N or CH; R 1 is a 5 or 6-substituent and is F is 19 F or 18 F; R 2 is NHCH 3 or N(CH 3 ) 2 . The compound of the present invention has high affinity to Aβ plaques and can be used to make appropriate radioactive nuclide labeling probes for early diagnosis of AD.

  一种含有手性侧链取代基的氟代2-芳基苯并杂环化合物，对Aβ斑块具有高亲和力，其一般化学式（I）如下：其中X为N；Y为S或O；Z为N或CH；R1为5或6-取代基，F为19F或18F；R2为NHCH3或N(CH3)2。本发明的化合物对Aβ斑块具有高亲和力，可用于制备适当的放射性核素标记探针，用于早期诊断阿尔茨海默病。
• [EN] 8-ARYL-4-ALKYLPYRROLO[2,3,4-DE]QUINOLIN-5(4H)-ONE AND 8-ARYL-4-ALKYL-4,5-DIHYDROPYRROLO[2,3,4-DE]QUINOLIN-5-OL DERIVATIVES<br/>[FR] DÉRIVÉS DE 8-ARYL-4-ALKYLPYRROLO[2,3,4-DÉ]QUINOLÉINE-5(4H)-ONE ET DE 8-ARYL-4-ALKYL-4,5-DIHYDROPYRROLO[2,3,4-DÉ]QUINOLÉINE-5-OL
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2009008552A1

  公开（公告）日：2009-01-15

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. An 8-aryl-4-alkylpyrrolo[2,3,4-de]quinolin-5(4H)-one or 8-aryl-4-alkyl-4,5-dihydropyrrolo[2,3,4-de]quinolin-5-ol derivative represented by the following formula [I], has a high affinity for CRF receptors, and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种CRF受体拮抗剂，该拮抗剂作为治疗或预防剂对CRF参与的疾病具有疗效，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮肤炎、精神分裂症、疼痛等。以下式[I]所代表的8-芳基-4-烷基吡咯并[2,3,4-de]喹啉-5(4H)-酮或8-芳基-4-烷基-4,5-二氢吡咯并[2,3,4-de]喹啉-5-醇衍生物具有高亲和力，对CRF参与的疾病具有疗效。
• Pyrrolopyrimidine Derivatives
  申请人：Bischoff P. Francois

  公开号：US20070270588A1

  公开（公告）日：2007-11-22

  According to the present invention, there is provided an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastro-intestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine derivative represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  根据本发明，提供了一种CRF受体拮抗剂，作为治疗或预防CRF参与的疾病的药物，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、斑秃、肠易激综合征、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等。以下式[I]所表示的吡咯吡嘧啶衍生物对CRF受体具有高亲和力，并对CRF参与的疾病有效。
• Indole Sulfonamide Modulators of Progesterone Receptors
  申请人：Bleisch Thomas John

  公开号：US20090069400A1

  公开（公告）日：2009-03-12

  Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed.

  本发明揭示了化学式（I）的化合物，其中n为1或2，R1、R2、R3、R4、R5、R6、R7和R8如本文所定义，其制备方法、药物组合物及使用方法。