三(咪唑-1-基)膦 | 73946-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 三(咪唑-1-基)膦
• 中文别名: 1H-吡咯并[3,2-d]嘧啶-2,4(3H,5H)-二酮,7-[(2S,3S,4R,5R)-3,4-二羟基-5-(羟甲基)-2-吡咯烷基]-
• 英文名称: Triimidazolylphosphine
• 英文别名: Tris(imidazol-1-yl)phosphine；tri(imidazol-1-yl)phosphane
• CAS: 73946-92-6
• 化学式: C₉H₉N₆P
• 分子量: 232.184
• InChiKey: HWOZVQNBUIBZMZ-UHFFFAOYSA-N

物化性质

• 熔点：
  154 °C
• 沸点：
  492.1±28.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三(咪唑-1-基)膦 生成 1-(9-苯基芴-9-基)咪唑
  参考文献：
  名称：

  YASUXO, XIDEHO;SADZI, IKUTARO;NAKASITA, MITSUO

  摘要：

  DOI：
• 作为产物：
  描述：

  三甲基硅咪唑 在 三氯化磷 作用下， 以 苯 为溶剂， 反应 0.5h， 生成 三(咪唑-1-基)膦
  参考文献：
  名称：

  Imidazo-oxazaphosphorines as Precursors to Chiral Phosphite Triesters

  摘要：

  New bicyclic imidazo-oxazaphosphorines underwent a highly diastereoselective displacement of the imidazole moiety upon reaction with various alcohols, leading to chiral phosphite triesters as single diastereomers. The introduction of a nucleoside on this bicyclic structure was investigated by several routes, leading to new nucleoside building blocks.

  DOI：

  10.1080/07328319808003465
• 作为试剂：
  描述：

  2,3,6,2',3',4',6'-hepta-O-acetyl-lactose 在 吡啶 、 三甲基乙酰氯 、 三(咪唑-1-基)膦 作用下， 以 乙腈 为溶剂， 反应 1.67h， 生成 Dec-9-enyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl phosphate triethylammonium salt
  参考文献：
  名称：

  Parasite glycoconjugates. Part 11.1 Preparation of phosphodisaccharide synthetic probes, substrate analogues for the elongating α-D-mannopyranosylphosphate transferase in the Leishmania

  摘要：

  在糖基化反应中使用柯尼希斯康诺尔法和三氯乙酰亚氨酸法，在表聚反应中使用三氟丙烯酯的 SN2 亲核置换法，在磷酸化反应中使用糖基膦酸氢盐法，合成了一组磷酸二糖（底物类似物），用于研究利什曼原虫生物合成酶的受体底物特异性。

  DOI：

  10.1039/b004653l

文献信息

• COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
  申请人：Glaser Gad

  公开号：US20110086813A1

  公开（公告）日：2011-04-14

  The present invention relates to a novel class of guanine nucleotide analogs which inhibit RelA and Relseq synthetic activity and which possess anti-bacterial activity. The present invention also relates to pharmaceutical compositions that include such compounds, and to methods of use of such compounds or compositions for combating bacteria and treating bacterial infections.

  本发明涉及一类新型鸟嘌呤核苷酸类似物，其抑制RelA和Relseq的合成活性，并具有抗细菌活性。本发明还涉及包括这些化合物的药物组合物，以及利用这些化合物或组合物来对抗细菌和治疗细菌感染的方法。
• Cyclic Phosphorylation Reaction of Diols with Tri(1-imidazolyl)phosphine
  作者：Takeo Shimidzu、Kazushige Yamana、Naoya Kanda、Susumu Kitagawa

  DOI：10.1246/bcsj.56.3483

  日期：1983.11

  Tri(1-imidazolyl)phosphine (1) gave the cyclic phosphite quantitatively in the reactions with the diols possessing favorably placed hydroxyl groups in which the distance between the two oxygen atoms is 2.7–3.0 A. The both five- and six-membered cyclic phosphites were obtained quantitatively from the reactions of the diols possessing flexible chains with 1. The course of the selective formation of ribonucleoside

  三（1-咪唑基）膦 (1) 在与具有有利位置羟基的二醇反应中定量生成环状亚磷酸酯，其中两个氧原子之间的距离为 2.7-3.0 A。五元环和六元环亚磷酸酯是从具有柔性链的二醇与 1 的反应中定量获得的。 核糖核苷 2',3'-环状 1-咪唑基亚膦酸酯的选择性形成过程被解释为 1 对 2'-或 3' 的较高反应性-羟基比朝向核糖核苷的 5'-羟基。
• Synthesis of N6,N6-Dialkyladenine Nucleosides Using Hexaalkylphosphorus Triamides Produced in Situ
  作者：Mahesh K. Lakshman、Asad Choudhury、Suyeal Bae、Eliezer Rochttis、Padmanava Pradhan、Amit Kumar

  DOI：10.1002/ejoc.200800752

  日期：——

  Reactions between secondary amines and phosphorus trichloride (PCl3) leads to the formation of the corresponding tris(dialkylamino)phosphines or hexaalkylphosphorus triamides [HAPT: (R2N)3P]. Reaction of silyl-protected 2'-deoxyinosine and acetyl-protected inosine with the in situ formed HAPT and iodine (I2) leads to the formation of N6,N6-dialkyl adenosine and 2'-deoxyadenosine. In some cases the

  仲胺与三氯化磷 (PCl3) 之间的反应导致形成相应的三（二烷基氨基）膦或六烷基磷三酰胺 [HAPT: (R2N)3P]。甲硅烷基保护的 2'-脱氧肌苷和乙酰基保护的肌苷与原位形成的 HAPT 和碘 (I2) 的反应导致形成 N6,N6-二烷基腺苷和 2'-脱氧腺苷。在某些情况下，胺的化学计量与叔胺碱的使用一样重要。通过 31 P1H} NMR 研究了胺化学计量对 HAPT 与 I2 反应的影响。
• Preparation of (2′-5′)-oligonucleotides based on 6-N-benzylaminopurineriboside using the Spicaria violacea fungal enzyme complex
  作者：T. I. Kulak、O. V. Tkachenko、O. Yu. Grishan、T. A. Kukharskaya、L. A. Eroshevskaya、E. N. Kalinichenko、A. I. Zinchenko

  DOI：10.1007/s10600-009-9249-6

  日期：2009.1

  A method for chemico-enzymatic synthesis of (2′-5′)-oligonucleotides with 6-N-benzylaminopurineriboside as the nucleoside units was proposed. The method consisted of enzymatic hydrolysis of the oligonucleotides with mixed (2′-5′)-(3′-5′)-phosphodiesterbonds that were prepared by polymerization of 6-N-benzyladenosine-2′(3′)-monophosphate by using (3′-5′)-specific nuclease and phosphatase contained in the filtrate of culture medium of the mycelial fungus Spicaria violacea.

  提出了一种以 6-N-苄基氨基嘌呤核苷酸为核苷酸单位的（2′-5′）寡核苷酸的化学酶法合成方法。该方法包括酶水解具有混合（2′-5′）-（3′-5′）-磷酸二酯键的寡核苷酸。(3′-5′)特异性核酸内切酶和磷酸酶，通过聚合 6-N- 苄基腺苷-2′(3′)-单磷酸制备而成。
• Synthetic Fragments of Antigenic Lipophosphoglycans fromLeishmania major andLeishmania mexicana and Their Use for Characterisation of theLeishmania Elongating ?-D-Mannopyranosylphosphate Transferase
  作者：Adrian P. Higson、Andrew J. Ross、Yury E. Tsvetkov、Fran�oise H. Routier、Olga V. Sizova、Michael A. J. Ferguson、Andrei V. Nikolaev

  DOI：10.1002/chem.200400563

  日期：2005.3.18

  and 6, which are fragments of the phosphoglycan portion of the surface lipophosphoglycans from Leishmania mexicana (5) or L. major (6-9), were synthesised by using the glycosyl hydrogenphosphonate method for the preparation of phosphodiester bridges. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania elongating alpha-D-mannosylphosphate transferase.

  通过利用酶切法合成了来自墨西哥利什曼原虫（5）或L.major（6-9）的表面脂磷酸聚糖的磷酸聚糖部分的片段的磷酸化的支链七糖7和8，八糖9和磷酸化的三糖5和6。用糖基氢膦酸酯方法制备磷酸二酯桥。测试化合物作为利什曼原虫延伸α-D-甘露糖基磷酸转移酶的受体底物/推定抑制剂。