4-propylphenylacetyl chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-propylphenylacetyl chloride
• 英文别名: (4-Propylphenyl)acetylchloride；2-(4-propylphenyl)acetyl chloride
• 化学式: C₁₁H₁₃ClO
• 分子量: 196.677
• InChiKey: AEJUXMQJFZEFAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-propylphenylacetyl chloride 在 三乙基硅烷 、 三氯化铝 作用下， 以 三氟乙酸 为溶剂， 生成 4-bromo-2-fluoro-1-[4-[2-(4-propylphenyl)ethyl]phenyl]benzene
  参考文献：
  名称：

  Fearon, J. E.; Gray, G. W.; Ifill, A. D., Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 124, p. 89 - 104

  摘要：

  DOI：
• 作为产物：
  描述：

  4-丙基苯乙酸 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 4-propylphenylacetyl chloride
  参考文献：
  名称：

  闭环烯烃-烯烃交叉偶联反应合成大内酰胺

  摘要：

  本文报道的是一种通过Rh（III）催化的闭环烯烃-烯烃交叉偶联反应合成大内酰胺的实用方法。反应是通过Rh催化的烯基sp 2 C–H活化过程进行的，该过程允许接触不同环大小的大环分子。含有共轭二烯骨架的大内酰胺可以很容易地以高化学选择性和Z，E立体选择性制备。

  DOI：

  10.1021/acs.orglett.0c03801

文献信息

• [EN] SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRAZINE DERIVATIVES AND 5,6,7,8-TETRAHYDRO-4H-PYRAZOLO[1,5-a][1,4]DIAZEPINE DERIVATIVES AS ROS1 INHIBITORS<br/>[FR] DÉRIVÉS 4,5,6,7-TÉTRAHYDRO-PYRAZOLO[1,5-A]PYRAZINE SUBSTITUÉS ET DÉRIVÉS 5,6,7,8-TÉTRAHYDRO-4H-PYRAZOLO[1,5-A][1,4]DIAZÉPINE UTILISÉS COMME INHIBITEURS DE ROS1
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2015144799A1

  公开（公告）日：2015-10-01

  The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine derivatives of formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as ROS 1 inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

  本发明涉及取代的4,5,6,7-四氢吡唑并[1,5-a]吡嗪衍生物和5,6,7,8-四氢-4H-吡唑并[1,5-a][1,4]二氮杂环衍生物的公式(I)中的变量具有权利要求中定义的含义。根据本发明的化合物可用作ROS 1抑制剂。本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物，以及将所述化合物用作药物的用途。
• Fluorine-substituted benzene derivative, liquid-crystal composition, and liquid-crystal display element
  申请人：Chisso Corporation

  公开号：US06210603B1

  公开（公告）日：2001-04-03

  Liquid crystalline compounds are provided which have an extremely high voltage holding ratio, altered only slightly by change of temperature, and which have a low threshold voltage and a high &Dgr;n. Also provided are liquid crystal compositions containing the liquid crystalline compound; and liquid crystal display devices containing the liquid crystal composition. The liquid crystalline compound is expressed by the general formula (1) wherein R, Y1 to Y16, X and Z1 to Z3 are defined in claim 1.

  提供了具有极高电压保持比的液晶化合物，其仅在温度变化时略有改变，并具有低阈值电压和高&Dgr;n。还提供了含有该液晶化合物的液晶组合物；以及含有液晶组合物的液晶显示装置。液晶化合物由一般式（1）表示，其中R、Y1至Y16、X和Z1至Z3在权利要求1中定义。
• Tolan compound and liquid crystal composition containing the same
  申请人：CHISSO CORPORATION

  公开号：EP0308747A2

  公开（公告）日：1989-03-29

  A liquid crystal substance having a low viscosity and good compatibility thereof with existing liquid crystals at low temperatures in addition to a large optical anisotropy value and a high clearing point and a liquid crystal composition containing the substance are provided, which substance is a 4-(trans-4-alkyl­cyclohexylmethyloxy)-4′-substituted-tolan expressed by the formula wherein R¹ is 1 - 10C alkyl and R² is 1 - 10C alkyl or alkoxy or F or Cℓ.

  本发明提供了一种液晶物质，除了具有较大的光学各向异性值和较高的澄明点外，还具有低粘度和在低温下与现有液晶的良好兼容性，以及含有该物质的液晶组合物，该物质是一种 4-(反式-4-烷基环己基甲基氧基)-4′-取代-托兰，其表达式为 其中 R¹ 为 1 - 10C 烷基，R² 为 1 - 10C 烷基或烷氧基或 F 或 Cℓ。
• FLUORINE-SUBSTITUTED BENZENE DERIVATIVES, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT
  申请人：CHISSO CORPORATION

  公开号：EP0949231A1

  公开（公告）日：1999-10-13

  Provided are liquid crystalline compounds which have an extremely high voltage holding ratio, are considerably small in its alteration caused by the change of temperature, and have a low threshold voltage and a high Δn; liquid crystal compositions comprising the liquid crystalline compound; and liquid crystal display devices fabricated by using the liquid crystal composition; the liquid crystalline compound is expressed by the general formula (1) wherein R represents an alkyl group having 1 to 20 carbon atoms in which alkyl group any not-adjacent methylene group (-CH2-) may be replaced by oxygen (-O-) atom; Y1 to Y16 independently represent hydrogen atom or fluorine atom, but at least three of them are fluorine atoms, provided that in no case three or more hydrogen atoms of one 1,4-phenylene group are replaced by fluorine atom; X represents a halogen atom or an alkyl group having 1 to 20 carbon atoms in which alkyl group any not-adjacent methylene group may be replaced by oxygen atom, and any hydrogen atom in the alkyl group may be replaced by fluorine atom; Z1, Z2, and Z3 independently represent -(CH2)2-, -(CH2)4-, -CH2O-, -OCH2-, -(CH2)3O-, -O(CH2)3-, or single bond; and any atom which constitutes this compound may be replaced by its isotope; provided that when X = -OCF2CF2H, Z1 = Z3 = single bond, and Z2 = -(CH2)2-, in no case Y6 = Y10 = Y12 = F, and Y1 to Y5 = Y7 to Y9 = Y11 = Y13 to Y16 = H; Y2 = Y10 = Y12 = F, and Y1 = Y3 to Y9 = Y11 = Y13 to Y16 = H; or Y2 = Y4 = Y10 = Y12 = F, and Y1 = Y3 = Y5 to Y9 = Y11 = Y13 to Y16 = H.

  本发明提供了具有极高电压保持率、温度变化对其影响极小、阈值电压低且Δn 高的液晶化合物；包含该液晶化合物的液晶组合物；以及使用该液晶组合物制造的液晶显示设备； 液晶化合物由通式（1）表示 其中 R 代表具有 1 至 20 个碳原子的烷基，在该烷基中，任何不相邻的亚甲基（-CH2-）可被氧原子（-O-）取代；Y1 至 Y16 独立地代表氢原子或氟原子，但其中至少有三个是氟原子，条件是在任何情况下，一个 1，4-亚苯基基团的三个或三个以上氢原子都不能被氟原子取代；X 代表卤素原子或具有 1 至 20 个碳原子的烷基，在该烷基中，任何不相邻的亚甲基可被氧原子取代，烷基中的任何氢原子可被氟原子取代；Z1、Z2 和 Z3 独立地代表-(CH2)2-、-(CH2)4-、-CH2O-、-OCH2-、-(CH2)3O-、-O(CH2)3- 或单键；构成该化合物的任何原子可被其同位素取代；但当 X = -OCF2CF2H、Z1 = Z3 = 单键和 Z2 = -(CH2)2- 时，在任何情况下均不得 Y6 = Y10 = Y12 = F，Y1 至 Y5 = Y7 至 Y9 = Y11 = Y13 至 Y16 = H； Y2 = Y10 = Y12 = F，且 Y1 = Y3 至 Y9 = Y11 = Y13 至 Y16 = H；或 Y2 = Y4 = Y10 = Y12 = F，Y1 = Y3 = Y5 至 Y9 = Y11 = Y13 至 Y16 = H。
• GOTO, YASUYUKI;SUDZUKI, TOSIXARU
  作者：GOTO, YASUYUKI、SUDZUKI, TOSIXARU

  DOI：——

  日期：——