methyl 3-(pyrrolidin-1-yl)hexanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 3-(pyrrolidin-1-yl)hexanoate
• 英文别名: Methyl 3-pyrrolidin-1-ylhexanoate；methyl 3-pyrrolidin-1-ylhexanoate
• 化学式: C₁₁H₂₁NO₂
• 分子量: 199.293
• InChiKey: AFJRTKXGCZGPHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 1-(叔丁基二甲基硅氧基)-1-甲氧基乙烯 、 正丁醛 在 N,N-diisopropyl-4H-benzo[d][1,3,2]dioxaborinin-2-amine 作用下， 以 N-甲基吡咯烷酮 为溶剂， 以94%的产率得到methyl 3-(pyrrolidin-1-yl)hexanoate
  参考文献：
  名称：

  Aminoboranes as “Compatible” Iminium Ion Generators in Aminative C−C Bond Formations

  摘要：

  Aminoboranes have been shown to be highly efficient and mild iminium ion generators in the Mannich-type aminative coupling of aldehydes with silyl ketene acetals. By using aminoboranes bearing bulky amino groups, such as a diisopropylamino group, free secondary amines can be successfully used as the amino component in a three-component Mannich reaction with aldehydes and silyl ketene acetals.

  DOI：

  10.1021/ja045827y

文献信息

• Aminoboranes as “Compatible” Iminium Ion Generators in Aminative C−C Bond Formations
  作者：Michinori Suginome、Lars Uehlin、Masahiro Murakami

  DOI：10.1021/ja045827y

  日期：2004.10.1

  Aminoboranes have been shown to be highly efficient and mild iminium ion generators in the Mannich-type aminative coupling of aldehydes with silyl ketene acetals. By using aminoboranes bearing bulky amino groups, such as a diisopropylamino group, free secondary amines can be successfully used as the amino component in a three-component Mannich reaction with aldehydes and silyl ketene acetals.