3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-1-phenyl-2-pyrazoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-1-phenyl-2-pyrazoline
• 英文别名: 5-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)-2-phenyl-3,4-dihydropyrazole
• 化学式: C₂₃H₂₁ClN₂O₂
• 分子量: 392.885
• InChiKey: AKXTYIHZEWEMCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(3,4-dimethoxyphenyl)-1-(4-chlorophenyl)-2-propen-1-one 、 苯肼 在 溶剂黄146 作用下， 反应 4.0h， 以92.1%的产率得到3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-1-phenyl-2-pyrazoline
  参考文献：
  名称：

  Synthesis and antidepressant activities of some 1,3,5-triphenyl-2-pyrazolines

  摘要：

  Ten new 1,3,5-triphenyl-2-pyrazoline derivatives were synthesized by reacting 1,3-diphenyl-2-propen-1-one with phenylhydrazine. The chemical structures of the compounds were proved by means of their UV, IR, H-1-NMR spectroscopic data and elementary analyses. The antidepressant activities of these compounds were screened by the Porsolt behavioral despair test. 1-Phenyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-2-pyrazoline and 1-phenyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-2-prazoline showed significant antidepressant activity compared with clomipramine and tranylcypromine. A methyl substituent on the phenyl ring at position 3 of the pyrazoline ring enhances the antidepressant activity; the replacement of this methyl group by chloro or bromo substituents decreases the activity. In addition, introduction of a chloro substituent to the phenyl at the position 5 decreases the antidepressant activity.

  DOI：

  10.1016/s0223-5234(96)80005-5

文献信息

• Kumar, Anjan; Rout, Sradhasini; Panda, Jnyanaranjan, Journal of the Indian Chemical Society, 2018, vol. 95, # 11, p. 1321 - 1326
  作者：Kumar, Anjan、Rout, Sradhasini、Panda, Jnyanaranjan、Sahoo, Biswa Mohan、Banik, Bimal Krishna

  DOI：——

  日期：——