3-methoxy-2-(2-pyridyl)thiophene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methoxy-2-(2-pyridyl)thiophene
• 英文别名: 2-(2-pyridyl)-3-methoxythiophene；2-(3-Methoxythiophen-2-yl)pyridine
• 化学式: C₁₀H₉NOS
• 分子量: 191.254
• InChiKey: ALJSPSDGQXGYRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  50.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-hydroxy-2-(2-pyridyl)thiophene 、 对甲苯磺酸甲酯 在 sodium hydride 作用下， 以 various solvent(s) 为溶剂， 反应 1.0h， 以77%的产率得到3-methoxy-2-(2-pyridyl)thiophene
  参考文献：
  名称：

  Zhang, Yihua; Hoernfeldt, Anna-Britta; Gronowitz, Salo, Journal of Heterocyclic Chemistry, 1993, vol. 30, # 5, p. 1293 - 1300

  摘要：

  DOI：

文献信息

• Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus
  作者：Jérémie Fournier dit Chabert、Béatrice Marquez、Luc Neville、Lionel Joucla、Sylvie Broussous、Pascale Bouhours、Emilie David、Stéphane Pellet-Rostaing、Bernard Marquet、Nicole Moreau、Marc Lemaire

  DOI：10.1016/j.bmc.2007.04.023

  日期：2007.7

  The synthesis based on palladium catalytic coupling of 38 new-arylated benzo[b]thiophenes or thiophenes is described in a few steps. We also report the direct arylation of the position 3 of the benzo[b]thiophenic structure, a 'one pot' 2,5-heterodiarylation of thiophenes as well as the synthesis of precursors of amino-acids with a 2-arylated benzo[b]thiophene core. These compounds were evaluated on bacteria strains: most of them did not exhibit any antibiotic activity but were found to selectively inhibit the NorA multidrug transporter of Staphylococcus aureus. As such, they restored the activity of the NorA substrates ciprofloxacin against a resistant S. aureus strain in which this efflux pump is over-expressed. (c) 2007 Elsevier Ltd. All rights reserved.
• [EN] COMPOSITION CONTAINING A THIOPHENIC OR BENZOTHIOPHENIC COMPOUND AND EXHIBITING A PUMP NORA INHIBITING ACTIVITY<br/>[FR] COMPOSITIONS CONTENANT UN COMPOSE THIOPHENIQUE OU BENZOTHIOPHENIQUE, PRESENTANT UNE ACTIVITE INHIBITRICE DE POMPE NORA
  申请人：UNIV CLAUDE BERNARD LYON

  公开号：WO2006018544A1

  公开（公告）日：2006-02-23

  La présente invention concerne l'utilisation d'inhibiteurs de pompe efflux NorA de formule (I) : tels que définis à la revendication 1, pour la préparation d'un médicament destiné à potentialiser l'effet d'un agent antimicrobien, ainsi que des compositions pour potentialiser l'effet d'un agent antimicrobien contenant, en tant qu'agent potentialisateur, un tel inhibiteur de pompe efflux NorA.
• Zhang, Yihua; Hoernfeldt, Anna-Britta; Gronowitz, Salo, Journal of Heterocyclic Chemistry, 1993, vol. 30, # 5, p. 1293 - 1300
  作者：Zhang, Yihua、Hoernfeldt, Anna-Britta、Gronowitz, Salo

  DOI：——

  日期：——