1-[3-(4-morpholinyl)propyl]-4-(4-fluorophenyl)-5-(4-pyridyl)imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[3-(4-morpholinyl)propyl]-4-(4-fluorophenyl)-5-(4-pyridyl)imidazole
• 英文别名: SB 210313；1-[3-(4-Morpholinyl)propyl]-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazole；4-{3-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-imidazol-1-yl]-propyl}-morpholine；4-[3-[4-(4-fluorophenyl)-5-pyridin-4-ylimidazol-1-yl]propyl]morpholine
• 化学式: C₂₁H₂₃FN₄O
• 分子量: 366.438
• InChiKey: ANWALZPQHPAZFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(3-氨丙基)吗啉 在 1,5,7-三氮杂双环[4.4.0]癸-5-烯 、 magnesium sulfate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 34.0h， 生成 1-[3-(4-morpholinyl)propyl]-4-(4-fluorophenyl)-5-(4-pyridyl)imidazole
  参考文献：
  名称：

  Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

  摘要：

  Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKC alpha and ERK kinase activity is observed. Copyright (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(96)00212-x

文献信息

• Formamide intermediates for the preparation of tri-substituted imidazole compounds with multiple therapeutic properties
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1227091A3

  公开（公告）日：2002-08-07

  The invention relates to a novel group of formamide compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.

  这项发明涉及一类新型的甲酰胺化合物及其制备方法，可用于制备具有多种治疗性能的三取代咪唑。
• Imine intermediates for the preparation of trisubstituted imidazole compounds with multiple therapeutic properties
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1229035A1

  公开（公告）日：2002-08-07

  The invention relates to a novel group of iminc compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.

  这项发明涉及一类新型的iminc化合物及其制备方法，可用于制备具有多种治疗性能的三取代咪唑。
• Isonitrile intermediates for the preparation of tri-substituted imidazole compounds with multiple therapeutic properties
  申请人：SmithKline Beecham Corporation

  公开号：EP1227092A3

  公开（公告）日：2002-08-07

  The invention relates to a novel group of isonitrile compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.

  这项发明涉及一类新型异腈化合物及其制备方法，可用于制备具有多种治疗性能的三取代咪唑。
• Compounds of the family of 3-alkyl-(4,5-diphenyl-imidazol-1-yl) and their use as soothing agents
  申请人：——

  公开号：US20040162328A1

  公开（公告）日：2004-08-19

  The invention concerns novel compounds of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), their synthesis method and cosmetic, hygienic or pharmaceutical compositions containing them The invention also concerns the use, in a physiologically acceptable medium, in or for preparing a soothing composition, of at least a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl). The invention further concerns the use, in a physiologically acceptable medium, in or for preparing a composition, a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), the compound and the composition being designed for soothing skin troubles such as sensitive skins, discomfort, gnawing, itching, irritations, red spots, heat and/or flush sensations, advantageously sensitive and/or irritable and/or reactive and/or allergic symptoms of the skin and/or the scalp and/or mucosa. Finally, the invention concerns a soothing cosmetic treatment using such a composition

  本发明涉及3-烷基-(4,5-二苯基-咪唑-1-基)家族的新化合物，其合成方法以及含有它们的化妆品、卫生或药物组合物。本发明还涉及在生理上可接受的介质中使用3-烷基-(4,5-二苯基-咪唑-1-基)家族的至少一个化合物制备舒缓组合物。本发明还涉及在生理上可接受的介质中使用3-烷基-(4,5-二苯基-咪唑-1-基)家族的化合物制备舒缓皮肤问题的组合物，例如敏感皮肤、不适、痒、刺激、红斑、热和/或潮红感，优选敏感和/或易激和/或反应和/或过敏症状的皮肤和/或头皮和/或粘膜。最后，本发明涉及使用这样的组合物进行舒缓化妆治疗。
• Novel compounds of the family of 3-alkyl-(4,5-diphenyl-imidazol-1-yl) and their use as soothing agents
  申请人：——

  公开号：US20040192928A1

  公开（公告）日：2004-09-30

  The invention concerns novel compounds of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), their synthesis method and cosmetic, hygienic or pharmaceutical compositions containing them. The invention also concerns the use, in a physiologically acceptable medium, in or for preparing a soothing composition, of at least a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl). The invention further concerns the use, in a physiologically acceptable medium, in or for producing a composition, of at least a compound of the family of 3-Alkyl-(4,5 diphenyl-imidazol-1-yl), the compound or the composition being designed to soothe skin troubles such as sensitive skins, discomfort, gnawing, itching, irritations, red spots, heat and/or flush sensations, advantageously sensitive and/or irritable and/or reactive and/or allergic symptoms of the skin and/or the scalp and/or mucosa. Finally, the invention concerns a soothing cosmetic method using such

  本发明涉及一类新的化合物，即3-烷基-(4,5-二苯基-咪唑-1-基)家族化合物，其合成方法以及含有它们的化妆品、卫生或药物组合物。本发明还涉及在生理上可接受的介质中，使用至少一种3-烷基-(4,5-二苯基-咪唑-1-基)家族化合物制备舒缓组合物的用途。本发明还涉及在生理上可接受的介质中，使用至少一种3-烷基-(4,5-二苯基-咪唑-1-基)家族化合物制备舒缓组合物的用途，该化合物或组合物旨在缓解皮肤问题，例如敏感皮肤、不适、咬痒、刺激、红斑、热感和/或潮红感，尤其是皮肤和/或头皮和/或黏膜的敏感和/或易怒和/或反应和/或过敏症状。最后，本发明涉及使用这种舒缓化妆方法。