Trichloroacetyl chloride appears as a colorless volatile liquid with a strong odor. Denser than water. Contact severely irritates skin, eyes and mucous membranes. May be very toxic by ingestion and inhalation. May be combustible.
颜色/状态:
Liquid
蒸汽压力:
21.32 mm Hg @ 25 °C, determined from experimentally derived coefficients
New labelling processes installed without adequate ventilation control in an electric motor factory exposed production line workers to toxic gases. Symptoms of eye & resp tract irritation & complaints of headache, fever, chills, dizziness, malaise, general weakness, nausea, & vomiting were reported in numerous cases. Chest signs, radiographic abnormalities, reduction in ventilatory function, & blood gas abnormalities were found in some cases. Epidemiological analysis of the spatial & temporal distribution of cases supported an exposure effect relationship. Investigations suggested ozone & possibly phosgene & assoc trichloroacetyl chlorides as the toxic agents that were generated by an ultraviolet print curing arrangement & perchloroethylene used as a cleaning solvent.
Dichloroacetylene (DCA) decomposes rapidly in contact with air into a series of chlorinated hydrocarbons which incl trichloroacetyl chloride. Expt were performed to compare mutagenic properties of DCA & its degradation products on the histidine-dependent tester strains TA98 & TA100 of Salmonella typhimurium. Trichloroacetyl chloride was not mutagenic in presence or absence of rat liver homogenate.
REACTIONS OF ATOMS AND FREE RADICALS IN SOLUTION. VIII. THE REACTION OF DIACETYL PEROXIDE WITH ALKYLBENZENES. A NEW SYNTHESIS OF HEXESTEROL DIMETHYL ETHER
[EN] PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS<br/>[FR] DÉRIVÉS DE PYRROLOTRIAZINONE EN TANT QU'INHIBITEURS DES PI3K
申请人:ALMIRALL SA
公开号:WO2014060432A1
公开(公告)日:2014-04-24
New pyrrolotriazinone derivatives having the chemical structure of formula (I), are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks)
TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE
申请人:Arvinas, Inc.
公开号:US20180125821A1
公开(公告)日:2018-05-10
The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.
Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
申请人:Failli A. Amedeo
公开号:US20060199806A1
公开(公告)日:2006-09-07
This invention provides pyrrolobenzodiazepine arylcarboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists, as well as pharmaceutical compositions and methods of treatment
Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists
申请人:Failli A. Amedeo
公开号:US20060287522A1
公开(公告)日:2006-12-21
This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).
New labile protecting groups for the anticipated synthesis of oligoribonucleotides were developed and introduced via their carbonochloridates 8 – 11 at the 5′-O position of thymidine (15) to form 16, 18, 21, and 24 in good yields (Schemes 2 and 3). Similarly, the 5′-O-diphenylphosphinoyl(dpp)-protected thymidine derivative 27 was synthesized with diphenylphosphinoyl chloride 14 as the reactive reagent