[6-(N-ethylcarbamoyl)-2-[4-(N-ethylcarbamoyl)phenyl]benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [6-(N-ethylcarbamoyl)-2-[4-(N-ethylcarbamoyl)phenyl]benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
• 英文别名: [6-(N-ethylcarbamoyl)-2-[4-(N-ethylcarbamoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone；[6-(N-Ethylcarbamoyl)-2[4-(N-ethylcarbamoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone；[6-(N-ethylcarbamoyl)-2-[4-(N-ethylcarbamoyl)phenyl]benzo[b]thien-3-yl][4-[2-(l-piperidyl)ethoxy]phenyl]methanone；N-ethyl-2-[4-(ethylcarbamoyl)phenyl]-3-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophene-6-carboxamide
• 化学式: C₃₄H₃₇N₃O₄S
• 分子量: 583.751
• InChiKey: AQULBTVAGMUVBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  盐酸雷洛昔芬 、 异氰酸乙酯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 [6-(N-ethylcarbamoyl)-2-[4-(N-ethylcarbamoyl)phenyl]benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
  参考文献：
  名称：

  Methods of treating neuropeptide Y-associated conditions

  摘要：

  这项发明描述了治疗与神经肽Y过量相关的疾病的方法，包括给予肥胖蛋白的类似物。这项发明进一步描述了治疗与神经肽Y过量相关的疾病的方法，包括给予肥胖蛋白的类似物结合神经肽Y拮抗剂。这项发明证明了肥胖蛋白通过减少下丘脑产生神经肽Y的作用。

  公开号：

  US06221838B1

文献信息

• Methods for treating resistant tumors
  申请人：Eli Lilly and Company

  公开号：US06124311A1

  公开（公告）日：2000-09-26

  The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.

  本发明提供了通过给需要治疗的哺乳动物使用取代吲哚、苯并呋喃、苯并噻吩、萘或二氢萘来逆转耐药新生物的方法。本发明还提供了治疗哺乳动物中的新生物的方法，包括向需要此治疗的哺乳动物施用取代吲哚、苯并呋喃、苯并噻吩、萘或二氢萘与一个溶瘤剂的组合。
• Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
  申请人：Eli Lilly and Company

  公开号：US05482949A1

  公开（公告）日：1996-01-09

  The present invention relates to sulfonate derivatives of 3-aroylbenzo[b]thiophenes, pharmaceutical formulations containing these compounds and methods of using such compounds for inhibiting the loss of bone, lowering serum cholesterol levels and therapeutically treating hormone dependent mammalian breast and uterine carcinoma.

  本发明涉及3-芳酰基苯并[b]噻吩的磺酸盐衍生物，含有这些化合物的制药配方以及使用这些化合物来抑制骨质流失、降低血清胆固醇水平和治疗激素依赖性哺乳动物乳腺和子宫癌的方法。
• Sulfonate and carbamate derivatives of 3-aroylbenzo[b] thiophenes
  申请人：Eli Lilly and Company

  公开号：US05605924A1

  公开（公告）日：1997-02-25

  The present invention relates to compounds of the formula ##STR1## where X is a bond or --CH2--; R.sup.2 is pyrrolidino; R is OH, --OSO.sub.2 --(CH.sub.2).sub.n --CH.sub.3 or ##STR2## R.sup.1 is hydrogen, OH, fluoro, chloro, --OSO.sub.2 --(CH.sub.2).sub.n --CH.sub.3 or ##STR3## each R.sup.3 is independently C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, unsubstituted or substituted phenyl where the substituent is fluoro, chloro, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; each n is independently 3, 4 or 5; and pharmaceutically acceptable salts and solvates thereof; provided that at least one of R and R.sup.1 is ##STR4## The invention also relates to methods of use of the compounds of formula I and pharmaceutical compositions which comprise compounds of formula I.

  本发明涉及式为##STR1##的化合物，其中X为键或--CH2--; R.sup.2为吡咯烷基; R为OH，--OSO.sub.2 --(CH.sub.2).sub.n --CH.sub.3或##STR2## R.sup.1为氢，OH，氟，氯，--OSO.sub.2 --(CH.sub.2).sub.n --CH.sub.3或##STR3##每个R.sup.3独立地为C.sub.1 -C.sub.6烷基，C.sub.3 -C.sub.6环烷基，未取代或取代苯基，其中取代基为氟，氯，C.sub.1 -C.sub.3烷基或C.sub.1 -C.sub.3烷氧基;每个n独立地为3,4或5;以及其药学上可接受的盐和溶剂合物; 前提是R和R.sup.1中至少有一个为##STR4## 本发明还涉及使用式I化合物的方法和包含式I化合物的药物组合物。
• Carbamate derivatives of 3-aroylbenzo[b] thiophenes
  申请人：Eli Lilly and Company

  公开号：US05994371A1

  公开（公告）日：1999-11-30

  The present invention relates to sulfonate and carbamate derivatives of 3-aroylbenzo[b]thiophenes, pharmaceutical formulations containing these compounds and methods of using such compounds for inhibiting the loss of bone, lowering serum cholesterol levels and therapeutically treating hormone dependent mammalian breast and uterine carcinoma.

  本发明涉及3-芳香基苯并噻吩的磺酸盐和氨基甲酸酯衍生物，包含这些化合物的药物配方以及使用这些化合物抑制骨质流失、降低血清胆固醇水平和治疗激素依赖性哺乳动物乳腺和子宫癌的方法。
• Sulfonate and carbamate derivatives of 3-aroylbenzo\x9bb!thiophenes
  申请人：Eli Lilly and Company

  公开号：US05798351A1

  公开（公告）日：1998-08-25

  The present invention relates to sulfonate and carbamate derivatives of 3-aroylbenzo\x9bb!thiophenes, pharmaceutical formulations containing these compounds and methods of using such compounds for inhibiting the loss of bone, lowering serum cholesterol levels and therapeutically treating hormone dependent mammalian breast and uterine carcinoma.

  本发明涉及3-芳酰基苯并[b]噻吩的磺酸盐和氨基甲酸酯衍生物，含有这些化合物的制药配方以及使用这些化合物抑制骨质流失、降低血清胆固醇水平和治疗激素依赖性哺乳动物乳腺和子宫癌的方法。