(E)-5-(4-methoxyphenyl)-2-methyl-pent-2-enoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-5-(4-methoxyphenyl)-2-methyl-pent-2-enoic acid
• 英文别名: (E)-5-(4-methoxyphenyl)-2-methylpent-2-enoic acid
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: ARPLMQIXEMCUKQ-ONNFQVAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  惕格酸 、 1-(碘甲基)-4-甲氧基苯 在 正丁基锂 、 二乙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 (E)-5-(4-methoxyphenyl)-2-methyl-pent-2-enoic acid
  参考文献：
  名称：

  丁烯酸二烯二醇锂的烷基化。烷基化剂的结构和离去基团的区域选择性作用

  摘要：

  丁-2-烯酸1和2被烷基卤化物烷基化的区域选择性在很大程度上取决于亲电试剂的反应性。饱和烷基卤化物的α选择性高，而高反应性烯丙基卤和苄基卤的α选择性差。对于反应性烷基化卤化物，选择性部分地由二烯二醇的离子对聚集体决定。正在进行的反应中生成的溴化锂和羧酸盐对区域选择性产生相反的影响。

  DOI：

  10.1016/s0040-4020(98)00149-5

文献信息

• New polymer materials for contact lens applications
  申请人：CIS Pharma AG

  公开号：US20200283560A1

  公开（公告）日：2020-09-10

  The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or more not-functionalized side chain-linked amino acids, (c) one or more functionalized side chain-linked amino acids, (d) a free radical initiator and, optionally, (e) a chain-transfer-agent. It also relates to block copolymers comprising the same monomers. The invention also encompasses silicone hydrogel contact lenses coated with or comprising the latter copolymers and block copolymers as well methods for introducing the copolymers and block copolymers into silicone hydrogel contact lenses.

  本发明涉及由聚合混合物制成的共聚物，所述聚合混合物包括（a）一种或多种可聚合单体，该单体被表征为至少具有一个乙烯基团且不含氨基酸残基，（b）一种或多种未功能化的侧链连接的氨基酸，（c）一种或多种功能化的侧链连接的氨基酸，（d）自由基引发剂，以及可选地，（e）链转移剂。还涉及包含相同单体的嵌段共聚物。该发明还涵盖涂有或包含后述共聚物和嵌段共聚物的硅水凝胶隐形眼镜，以及将这些共聚物和嵌段共聚物引入硅水凝胶隐形眼镜的方法。
• Biocompatible polymers and co-polymers, and uses thereof
  申请人：Hitz Hans

  公开号：US20090232871A1

  公开（公告）日：2009-09-17

  The invention relates to highly biocompatible or biophilic un-cross-linked or cross-linked polymers comprising one or more side-chain active acrylic amino acids of formula I wherein: X is —NH(CH 2 ) 4 —, —O—C 6 H 4 —CH 2 —, —OCH 2 —, —O—CH(CH 3 )—, —S—CH 2 —, —O-proline, and R is H or CH 3 ; and wherein the polymer further includes a free radical initiator and, optionally, a cross-linking agent having a plurality of polymerizable ethylenically unsaturated groups. The invention further concerns various highly biocompatible, cross-linked co-polymers comprising one or more monomers of formula I, and one or more other polymerizable monomers. Uses of such polymers and co-polymers for the production of contact lenses, intraocular lenses, implants, wound healing slabs, additives for food and cosmetics, conductive plastics, spinnable fibers, and the like are disclosed.

  本发明涉及高生物相容性或亲生性的未交联或交联聚合物，其包括一个或多个侧链活性丙烯酸氨基酸（公式I），其中：X为—NH（CH2）4—，—O—C6H4—CH2—，—OCH2—，—O—CH（CH3）—，—S—CH2—，—O-脯氨酸，R为H或CH3；聚合物进一步包括自由基引发剂和可选的具有多个可聚合乙烯基不饱和基团的交联剂。本发明还涉及各种高生物相容性的交联共聚物，其中包括一个或多个公式I的单体和一个或多个其他可聚合单体。本发明还揭示了这些聚合物和共聚物的用途，用于生产隐形眼镜、人工晶体、植入物、伤口愈合垫、食品和化妆品添加剂、导电塑料、可旋转纤维等。
• Acrylic copolymer materials suitable for ophthalmic devices
  申请人：Nidek Co., Ltd.

  公开号：EP1035142A1

  公开（公告）日：2000-09-13

  The present invention relates to acrylic copolymer materials, useful for forming ophthalmic devices, and process for making the same. The acrylic copolymer material comprises polymer units derived from an α,β-ethylenically unsaturated carboxylic acid monomer and an aryl (meth)acrylate monomer. Specifically, an α,β-ethylenically unsaturated carboxylic acid monomer represented by formula (I): wherein R1 and R2 independently represent a hydrogen atom or an alkyl group having up to 6 carbon atoms, and R3 represents a hydrogen atom or a methyl group; and an aryl (meth)acrylate monomer represented by formula (II): wherein X represents a hydrogen atom or a methyl group, and R represents a covalent bond, or a substituted or unsubstituted hydrocarbyl group and Ar is any aromatic ring, such as benzene, which can be unsubstituted or substituted with H, CH3, C2H5, n-C3H7, iso-C3H7, OCH3, C6H11, Cl, Br, C6H5 or CH2C6H5.

  本发明涉及可用于制造眼科设备的丙烯酸共聚物材料及其制造工艺。丙烯酸共聚物材料由α,β-乙烯基不饱和羧酸单体和芳基（甲基）丙烯酸酯单体衍生的聚合物单元组成。具体来说，α，β-乙烯基不饱和羧酸单体由式（I）表示： 其中 R1 和 R2 分别代表氢原子或最多 6 个碳原子的烷基，R3 代表氢原子或甲基；以及由式 (II) 代表的芳基（甲基）丙烯酸酯单体： 其中 X 代表氢原子或甲基，R 代表共价键或取代或未取代的烃基，Ar 是任何芳香环，如苯，可以未取代或被 H、CH3、C2H5、n-C3H7、异-C3H7、OCH3、C6H11、Cl、Br、C6H5 或 CH2C6H5 取代。
• Thermoplastic resin composition and molded product made using the same
  申请人：Cheil Industries Inc.

  公开号：EP2184321A2

  公开（公告）日：2010-05-12

  Disclosed is a thermoplastic resin composition that includes (A) a polycarbonate resin, (B) a modified acryl-based copolymer resin, (C) a polysiloxane copolymer including an aryl group, and (D) a core-shell graft copolymer.

  公开了一种热塑性树脂组合物，其中包括 (A) 聚碳酸酯树脂，(B) 改性丙烯酸基共聚物树脂，(C) 包括芳基的聚硅氧烷共聚物，以及 (D) 芯壳接枝共聚物。
• Thermoplastic resin composition revealing improved impact strength and melt flow property
  申请人：Cheil Industries Inc.

  公开号：EP2341102A1

  公开（公告）日：2011-07-06

  The styrenic thermoplastic resin composition having excellent impact strength of the present invention comprises (A) about 10 to about 99% by weight of a thermoplastic resin including one or more compounds selected from the group consisting of styrenic copolymer resin(a1) and rubber-modified vinyl graft copolymer(a2);and (B) about 1 to about 90% by weight of a branched styrenic copolymer resin prepared by including a silicon based compound. The thermoplastic resin composition of the present invention is a resin composition having improved flow property, compactibility and impact strength as applying branched styrenic copolymer resin.

  本发明的具有优异冲击强度的苯乙烯类热塑性树脂组合物包括：(A)约 10%至约 99% （按重量计）的热塑性树脂，其中包括选自苯乙烯类共聚物树脂（a1）和橡胶改性乙烯基接枝共聚物 （a2）组中的一种或多种化合物；以及(B)约 1%至约 90%（按重量计）的支链苯乙烯类共聚物树脂， 该支链苯乙烯类共聚物树脂通过加入硅基化合物制备而成。 本发明的热塑性树脂组合物是一种树脂组合物，与应用支链苯乙烯共聚物树脂一样， 具有更好的流动性、密实性和冲击强度。