IT IS...LOW IN SINGLE-DOSE TOXICITY WHEN INJECTED IP, SINCE THE LD50 FOR RATS IS 1.41 ML/KG. ...EYE CONTACT SHOULD GIVE RISE TO NO SIGNIFICANT IRRITATION NOR IS IT LIKELY TO BE ABSORBED THROUGH THE SKIN IN TOXIC AMOUNTS...
来源:Hazardous Substances Data Bank (HSDB)
毒理性
非人类毒性摘录
在大约20°C下，大鼠单次暴露于基本饱和蒸气8小时，没有产生显著的不良影响。
A SINGLE 8-HR EXPOSURE OF RATS TO ESSENTIALLY SATURATED VAPORS GENERATED AT APPROX 20 °C RESULTED IN NO SIGNIFICANT ADVERSE EFFECTS.
Triethylene glycol and two of its derivatives were evaluated for reproductive toxicity in a continuous breeding protocol with Swiss CD-1 mice. Triethylene glycol (TEG: 0, 0.3, 1.5, and 3%), triethylene glycol diacetate (TGD: 0, 0.75, 1.5, and 3%), and triethylene glycol dimethyl ether (triethylene glycol dimethyl ether: 0, 0.25, 0.5, and 1%) were administered in drinking water to breeding pairs (20 pairs per treatment groups, 40 control pairs) during a 98-day cohabitation period. Reproductive function was assessed by the number of litters per pair, live pups per litter, proportion of pups born alive, and pup weight. There were no apparent effects on reproductive function in the animals receiving triethylene glycol or triethylene glycol diacetate at doses up to 3% in the drinking water (representing 6.78 or 5.45 g/kg, respectively). However, some developmental toxicity was demonstrated for both triethylene glycol and triethylene glycol diacetate. Continuous exposure of dams to 1.5 or 3% triethylene glycol significantly reduced live pup weight at birth compared to control and 0.3% triethylene glycol significantly reduced live pup weight at birth compared to control and 0.3% triethylene glycol. while exposure to 3% triethylene glycol diacetate during lactation significantly (but reversibly) reduced pup body weights on Postnatal Days 14 and 21. In contrast, triethylene glycol dimethyl ether was toxic to the reproductive system as evidenced by decreases at the highest does (1% triethylene glycol dimethyl ether; 1.47 g/kg) in the proportion of pairs that produced at least one litter, live pups per litter, and proportion of pups born alive, with dose-related trends seen in the latter two parameters. A crossover mating trial showed that triethylene glycol dimethyl ether was more toxic to the female than the male reproductive system. These data indicate that triethylene glycol dimethyl ether (1.47 g/kg) is a reproductive toxicant in Swiss mice while reproductive toxicity was not demonstrated in mice receiving triethylene glycol or triethylene glycol diacetate (at doses up to 6.78 or 5.45 g/kg, respectively).
[EN] SYNTHESIS OF CHROMANOL AND 2-METHYL-1,4-NAPHTHOQUINONE DERIVATIVES<br/>[FR] SYNTHÈSE DE DÉRIVÉS DE CHROMANOL ET DE 2-MÉTHYL-1,4-NAPHTOQUINONE
申请人：BASF SE
公开号：WO2020035601A1
公开（公告）日：2020-02-20
The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.
[EN] SYNTHESIS OF CHROMANOL DERIVATIVES<br/>[FR] SYNTHÈSE DE DÉRIVÉS DE CHROMANOL
申请人：BASF SE
公开号：WO2020035600A1
公开（公告）日：2020-02-20
The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula (I) wherein R1, R2 and R3 independently of each other are selected from hydrogen and methyl, R4 is selected from hydrogen and C1-C6-alkanoyl, and X is selected from C1-C20-alkyl and C2-C20-alkenyl.
Catalytic enantioselective addition of hydrocarbon equivalents to alpha,
申请人：Massachusettes Institute of Technology
公开号：US04962214A1
公开（公告）日：1990-10-09
The conjugate addition of Grignard reagents to alpha, beta-unsaturated carbonyl compounds using a series of novel catalysts is described. The catalysts comprise copper(I) complexes with ligand systems comprising either tropocoronand macrocycles or N,N'-dialkylsubstituted aminotroponeimines.
The use of nano-silica melamine trisulfonic acid as a reusable heterogeneous solid acidcatalyst in the esterification reaction of carboxylic acids and alcohols is reported. The reaction conditions were optimized by testing temperature, each component of catalyst, feedstock ratios as well as load of catalyst. The synthesized catalyst was characterized by X-ray diffraction, scanning electron microscopy
Photoimageable compositions having improved chemical resistance and stripping ability
申请人：Shipley Company LLC
公开号：EP1008912A1
公开（公告）日：2000-06-14
A negative-acting photoimageable composition useful as a primary imaging resist in the manufacture of printed circuit boards comprises an acid-functional binder polymer, a photopolymerizable component, and a photoinitiator chemical system, in which the binder polymer has an anhydride functional backbone half-esterified with a meth(acrylate) functional hydroxy-terminated oligomer, wherein the meth(acrylate) functionality is separated from the half-ester linkage by at least two alkoxylate groups and at least one ring opened lactone group for improved stripping ability in strong alkaline aqueous stripping solutions, while maintaining good chemical resistance to other processing chemicals, such as alkaline developing solutions, acid etching solutions, and acid plating baths.
