(4R,5S)-2,2-Dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4R,5S)-2,2-Dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester
• 英文别名: Methyl 2,2-dimethyl-5-phenyl-1,3-dioxolane-4-carboxylate
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: ATJYPZWFJIJBKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4R,5S)-2,2-Dimethyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester 在 硝酸铵 、 Montmorillonite-K₁₀ 作用下， 反应 0.04h， 以70%的产率得到methyl 2,3-dihydroxy-3-phenylpropionate
  参考文献：
  名称：

  Microwave Thermolysis V: A Rapid and Selective Method for the Cleavage of THP Ethers, Acetals and Acetonides Using Clay Supported Ammonium Nitrate “Clayan” in Dry Media

  摘要：

  The deprotection of a variety of tetrahydropyranyI ethers (THP), acetonides and acetals into their parent compounds using clay supported ammonium nitrate "Clayan" under microwave irradiation is described. The eco-friendly nature of the reagent and non solvent conditions are the important features of the procedure.

  DOI：

  10.1080/00397919908086448

文献信息

• PHENYLALKYL SULFAMATE COMPOUND AND MUSCLE RELAXANT COMPOSITION COMPRISING THE SAME
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：EP2861571B1

  公开（公告）日：2017-05-03
• Microwave Thermolysis V: A Rapid and Selective Method for the Cleavage of THP Ethers, Acetals and Acetonides Using Clay Supported Ammonium Nitrate “Clayan” in Dry Media
  作者：H. M. Meshram、G. Sumithra、G. S. Reddy、Y. S. S. Ganesh、J. S. Yadav

  DOI：10.1080/00397919908086448

  日期：1999.8

  The deprotection of a variety of tetrahydropyranyI ethers (THP), acetonides and acetals into their parent compounds using clay supported ammonium nitrate "Clayan" under microwave irradiation is described. The eco-friendly nature of the reagent and non solvent conditions are the important features of the procedure.