shomaside A

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: shomaside A
• 英文别名: (2R,3S)-2-[(3,4-dihydroxyphenyl)methyl]-2-hydroxy-3-[3-[3-methoxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-enoyloxy]butanedioic acid
• 化学式: C₂₇H₃₀O₁₆
• 分子量: 610.526
• InChiKey: AVWHRYVRVICHPX-CDDMBSAOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  270
• 氢给体数：
  9
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  shomaside A 在 盐酸 、 水 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 β-半乳糖苷酶
  参考文献：
  名称：

  Hyaluronidase Inhibitors from “Cimicifugae Rhizoma” (a Mixture of the Rhizomes of Cimicifuga dahurica and C. heracleifolia)

  摘要：

  From the 80% acetone extract of "Cimicifugae Rhizoma" (a mixture of Cimicifuga dahurica and C. heracleifolia used medicinally), seven new fukiic acid derivatives (1-7) and a new phenylethanoid derivative (8) were isolated along with eight known compounds (9-16). Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid.

  DOI：

  10.1021/np900675n

文献信息

• Hyaluronidase Inhibitors from “Cimicifugae Rhizoma” (a Mixture of the Rhizomes of <i>Cimicifuga dahurica</i> and <i>C. heracleifolia</i>)
  作者：Atsufumi Iwanaga、Genjiro Kusano、Tsutomu Warashina、Toshio Miyase

  DOI：10.1021/np900675n

  日期：2010.4.23

  From the 80% acetone extract of "Cimicifugae Rhizoma" (a mixture of Cimicifuga dahurica and C. heracleifolia used medicinally), seven new fukiic acid derivatives (1-7) and a new phenylethanoid derivative (8) were isolated along with eight known compounds (9-16). Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid.