sarcosine n-butyl ester hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: sarcosine n-butyl ester hydrochloride
• 英文别名: Butyl 2-(methylamino)acetate;hydrochloride；butyl 2-(methylamino)acetate;hydrochloride
• 化学式: C₇H₁₅NO₂*ClH
• 分子量: 181.663
• InChiKey: AXZMOTOPTJCPFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sarcosine n-butyl ester hydrochloride 在 四丁基氟化铵 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 44.0h， 生成 (5R,6S)-3-[(Butoxycarbonylmethyl-methyl-amino)-methyl]-6-((R)-1-hydroxy-ethyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester
  参考文献：
  名称：

  2-取代的具有与氨基酸相关的侧链的Penems：新系列的β-内酰胺类抗生素的合成和抗菌活性。

  摘要：

  合成了一系列新的6-（羟乙基）青霉烯2-氨基酸相关的侧链取代。从合成的观点来看，氨基酰基衍生物的性质被证明是至关重要的，因为β-内酰胺开环可以与C-2亲核取代竞争，并且具有抗菌活性。伯氨基酸酰胺作为增强通过革兰氏阴性外膜渗透性的最合适的侧链出现。新的2-[（（氨基酰胺基）甲基]青霉烯3a-u）的体外活性受酰胺部分的性质和位置，环状酰胺的环大小以及氨基酸构型的影响。

  DOI：

  10.1021/jm00021a013

文献信息

• The first iodine improved 1,3-dipolar cycloaddition: facile and novel synthesis of 2-substituted benzo[f]isoindole-4,9-diones
  作者：Huan-Ming Huang、Jian-Rong Gao、Li-Fen Hou、Jian-Hong Jia、Liang Han、Qing Ye、Yu-Jin Li

  DOI：10.1016/j.tet.2013.08.029

  日期：2013.10

  The first novel protocol of the synthesis of 2-substituted benzo[f]isoindole-4,9-dione framework via the one-pot, 1,3-dipolar cycloaddition of quinones, paraformaldehyde and N-substituted amino ester hydrochlorides in the present of iodine at refluxing acetonitrile was reported. All these reactions proceed with good to excellent yields. The promising results obtained 1,3-dipolar cycloaddition will

  的合成的第一新颖协议的2-取代的苯并[ ˚F ]通过的醌类，多聚甲醛和一锅煮，1,3-偶极环加成异吲哚-4,9-二酮框架Ñ本的取代的氨基酯盐酸盐碘在回流的乙腈进行了报道。所有这些反应均以良好至极好的收率进行。1,3-偶极环加成反应获得的有希望的结果将在具有重要生物活性的天然产物中具有潜在的应用前景。
• [EN] SYNTHETIC TRITERPENOIDS WITH NITROGEN-BASED SUBSTITUENTS AT C-17 AND METHODS OF USE THEREOF<br/>[FR] TRITERPÉNOÏDES SYNTHÉTIQUES COMPRENANT DES SUBSTITUANTS À BASE D'AZOTE EN C-17 ET LEURS MÉTHODES D'UTILISATION
  申请人：REATA PHARMACEUTICALS INC

  公开号：WO2021127480A1

  公开（公告）日：2021-06-24

  In some aspects, the present disclosure provides compounds of the formula: (I) and (II), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.

  在某些方面，本公开提供了以下式(I)和(II)的化合物，其中变量在此处定义。还提供了这些药物组合物。在某些方面，本文提供的化合物和组合物可用作抗氧化炎症调节剂。在某些方面，本公开提供了方法，其中所描述的化合物和组合物用于治疗与炎症和癌症相关的疾病和疾病。
• Composition, cured product, storage container, image forming apparatus, and image forming method
  申请人：RICOH COMPANY, LTD.

  公开号：US11208516B2

  公开（公告）日：2021-12-28

  Provided is a composition including an acrylamide compound having a molecular weight of 150 or greater but 250 or less (A1), and a monomer having a cyclic structure represented by General Formula (3) below, or General Formula (4) below, or both (A2), where, in General Formulae (3) and (4), L is a single bond or a straight chain or branched alkylene group that has from 1 through 10 carbon atoms and may include an oxygen atom, a nitrogen atom, or a sulfur atom; A is a cyclic structure that has from 2 through 10 carbon atoms and may include an oxygen atom, a nitrogen atom, or a sulfur atom; R6 is a hydrogen atom or a methyl group; and R7 and R8 are each a straight chain or branched alkyl group having from 1 through 10 carbon atoms.

  本发明提供了一种组合物，其中包括分子量大于或等于 150 但小于或等于 250 的丙烯酰胺化合物（A1），以及具有下式（3）或下式（4）或两者所代表的环状结构的单体（A2）、 其中，在通式（3）和（4）中，L 是单键或直链或支链亚烷基，具有 1 到 10 个碳原子，可包括氧原子、氮原子或硫原子；A 是环状结构，具有 2 到 10 个碳原子，可包括氧原子、氮原子或硫原子；R6 是氢原子或甲基；R7 和 R8 分别是直链或支链烷基，具有 1 到 10 个碳原子。
• COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE
  申请人：Pfizer Limited

  公开号：EP1242120A2

  公开（公告）日：2002-09-25
• COMPOSITION, CURED PRODUCT, STORAGE CONTAINER, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD
  申请人：KOBAYASHI Masahide

  公开号：US20200031969A1

  公开（公告）日：2020-01-30

  Provided is a composition including an acrylamide compound having a molecular weight of 150 or greater but 250 or less (A1), and a monomer having a cyclic structure represented by General Formula (3) below, or General Formula (4) below, or both (A2), where, in General Formulae (3) and (4), L is a single bond or a straight chain or branched alkylene group that has from 1 through 10 carbon atoms and may include an oxygen atom, a nitrogen atom, or a sulfur atom; A is a cyclic structure that has from 2 through 10 carbon atoms and may include an oxygen atom, a nitrogen atom, or a sulfur atom; R 6 is a hydrogen atom or a methyl group; and R 7 and R 8 are each a straight chain or branched alkyl group having from 1 through 10 carbon atoms.