三磷酸假尿苷

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 三磷酸假尿苷
• 英文名称: N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water)
• 英文别名: [[3,4-dihydroxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₀H₁₇N₂O₁₅P₃
• 分子量: 498.17
• InChiKey: OLRONOIBERDKRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  259
• 氢给体数：
  7
• 氢受体数：
  15

文献信息

• TREATMENT INVOLVING INTERLEUKIN-2 (IL2) AND INTERFERON (IFN)
  申请人：BIONTECH SE

  公开号：US20220143144A1

  公开（公告）日：2022-05-12

  The present disclosure relates to methods and agents for enhancing the effect of immune effector cells, in particular immune effector cells that respond to interleukin-2 (IL2), for example effector T cells such as CD8+ T cells. Specifically, the present disclosure relates to methods comprising administering to a subject a polypeptide comprising IL2 or a functional variant thereof or a polynucleotide encoding a polypeptide comprising IL2 or a functional variant thereof and a polypeptide comprising type I interferon (IFN) or a functional variant thereof or a polynucleotide encoding a polypeptide comprising type I interferon or a functional variant thereof.

  本公开涉及增强免疫效应细胞的方法和药剂，特别是对介白质-2（IL2）作出反应的免疫效应细胞，例如效应T细胞（如CD8+ T细胞）。具体而言，本公开涉及的方法包括向受试者给予包含IL2或其功能变体的多肽或编码包含IL2或其功能变体的多肽的多核苷酸和包含I型干扰素（IFN）或其功能变体的多肽或编码包含I型干扰素或其功能变体的多肽的多核苷酸。
• Therapeutic RNA
  申请人：Sanofi

  公开号：US20200147176A1

  公开（公告）日：2020-05-14

  This disclosure relates to the field of therapeutic RNAs for treatment of solid tumor cancers.
• HIGH EXPRESSION mRNA SWITCH
  申请人：KYOTO UNIVERSITY

  公开号：US20210079440A1

  公开（公告）日：2021-03-18

  The present invention provides an mRNA switch which has improved expression level and sensitivity. An mRNA comprising: (i) a nucleic acid sequence specifically recognized by a miRNA or protein; and (ii) a nucleic acid sequence corresponding to a coding region for a marker protein, wherein a nucleotide contained in the mRNA comprises N 1 -methyl pseudouridine.
• [EN] THERAPEUTIC RNA FOR TREATING CANCER<br/>[FR] ARN THÉRAPEUTIQUE POUR LE TRAITEMENT DU CANCER
  申请人：[en]BIONTECH SE

  公开号：WO2022136257A1

  公开（公告）日：2022-06-30

  This disclosure relates to the field of therapeutic RNA to treat cancer. Disclosed herein are compositions, uses, and methods for treatment of cancers. Administration of therapeutic RNAs to a patient having cancer disclosed herein can reduce tumor size, prolong time to progressive disease, and/or protect against metastasis and/or recurrence of the tumor and ultimately extend survival time.