9-ethyl-3-(4-fluorobenzoyl)-9H-carbazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-ethyl-3-(4-fluorobenzoyl)-9H-carbazole
• 英文别名: (9-Ethylcarbazol-3-yl)-(4-fluorophenyl)methanone
• 化学式: C₂₁H₁₆FNO
• 分子量: 317.363
• InChiKey: BCOJHFLANMVQSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-ethyl-3-(4-fluorobenzoyl)-9H-carbazole 、 邻甲基苯甲酰氯 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 生成 [9-ethyl-6-(2-methyl-benzoyl)-carbazol-3-yl]-(4-fluoro-phenyl)-methanone
  参考文献：
  名称：

  WO2008/138724

  摘要：

  公开号：
• 作为产物：
  描述：

  咔唑 在 aluminum (III) chloride 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 17.33h， 生成 9-ethyl-3-(4-fluorobenzoyl)-9H-carbazole
  参考文献：
  名称：

  Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells

  摘要：

  Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked to the nitrogen of the carbazole and a carbonyl moiety linked to distinct biaromatic rings exhibited remarkably different killing activities in human GBM cell lines and patient-derived GBM cells, with IC50 values from 67 to > 10,000 nM. Measures of the activity of modified carbazoles with tubulin and microtubules coupled to molecular docking studies show that these compounds bind to the colchicine site of tubulin in a unique low interaction space that inhibits tubulin assembly. The modified carbazoles reported here represent novel chemical tools to better understand how small molecules disrupt MT functions and kill devastating cancers such as GBM. (C) 2018 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2018.09.026

文献信息

• PHOTOACTIVE COMPOUND AND PHOTOSENSITIVE RESIN COMPOSITION COMPRISING THE SAME
  申请人：Cho Chang Ho

  公开号：US20100261815A1

  公开（公告）日：2010-10-14

  A novel photoactive compound is provided. The photoactive compound has a structure represented by Formula 1: wherein R 1 , R 2 , R 3 , A, X, Y, n and m are as defined in the specification. The photoactive compound efficiently absorbs UV light. Accordingly, the photoactive compound has an improved ability to generate radicals and is efficiently photopolymerized with unsaturated bonds. Further provided is a photosensitive resin composition comprising the photoactive compound. The photosensitive resin composition has good sensitivity because it efficiently absorbs UV light. In addition, the photosensitive resin composition has excellent characteristics in terms of residual film ratio, mechanical strength and resistance to heat, chemicals and development. Therefore, the photosensitive resin composition is advantageously used in curing materials for column spacers, overcoats and passivation films of liquid crystal display devices. In addition, the photosensitive resin composition has excellent thermal processing characteristics.

  提供了一种新型光敏化合物。该光敏化合物的结构如公式1所示：其中，R1、R2、R3、A、X、Y、n和m的定义如规范中所述。该光敏化合物能够高效吸收紫外线。因此，该光敏化合物具有改善产生自由基的能力，并且能够高效光聚合不饱和键。此外，还提供了一种包括该光敏化合物的光敏树脂组合物。该光敏树脂组合物具有良好的敏感性，因为它能够高效吸收紫外线。此外，该光敏树脂组合物在残留膜比、机械强度、耐热性、耐化学品和开发方面具有优异的特性。因此，该光敏树脂组合物可以优势地用于液晶显示器件的柱间距材料、覆盖层和钝化膜的固化材料。此外，该光敏树脂组合物具有优异的热加工特性。
• [EN] PHOTOINITIATOR COMPOSITION CONTAINING ACYLCARBAZOLE DERIVATIVE AND CARBAZOLYL OXIME ESTER, AND USE THEREOF IN PHOTOCURABLE COMPOSITION<br/>[FR] COMPOSITION DE PHOTOINITIATEUR CONTENANT UN DÉRIVÉ D'ACYLCARBAZOLE ET UN ESTER D'OXIME DE CARBAZOLYLE, ET SON UTILISATION DANS UNE COMPOSITION PHOTODURCISSABLE<br/>[ZH] 一种含有酰基咔唑衍生物和咔唑基肟酯的光引发剂组合物及其在光固化组合物中的应用
  申请人：INSIGHT HIGH TECH JIANGSU CO LTD

  公开号：WO2020253284A1

  公开（公告）日：2020-12-24

  本发明提供一种含有酰基咔唑衍生物和咔唑基肟酯的光引发剂组合物，将此光引发剂组合物应用于光固化组合物尤其是光刻胶配方中，当酰基咔唑衍生物与咔唑基肟酯光引发剂的摩尔比在0.1～1.4之间显示了最佳的增感效果。
• MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS
  申请人：UNIVERSITY OF WASHINGTON

  公开号：US20210094949A1

  公开（公告）日：2021-04-01

  This disclosure relates to compounds that target microtubules, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases. More particularly, this disclosure relates to modified carbazole compounds and pharmaceutical compositions thereof, methods of targeting microtubules with these compounds, and methods of treating diseases affected by microtubule disruption.
• PHOTOINITIATOR COMPOSITION CONTAINING ACYLCARBAZOLE DERIVATIVE AND CARBAZOLYL OXIME ESTER, AND USE THEREOF IN PHOTOCURABLE COMPOSITION
  申请人：IGM (ANQING) HIGH TECHNOLOGY DEVELOPMENT CO., LTD

  公开号：US20220179309A1

  公开（公告）日：2022-06-09

  Provided is a photoinitiator composition containing an acylcarbazole derivative and a carbazolyl oxime ester. The photoinitiator composition is used in a photocurable composition, especially a photoresist formulation, and exhibits the best sensibilization effect when the molar ratio of the acylcarbazole derivative to the carbazolyl oxime ester photoinitiator is between 0.1 and 1.4.
• US8252507B2
  申请人：——

  公开号：US8252507B2

  公开（公告）日：2012-08-28