2,2,2-trifluoro-1-(2-phenylaminophenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,2-trifluoro-1-(2-phenylaminophenyl)ethanone
• 英文别名: 2,2,2-trifluoro-1-(2-anilinophenyl)ethanone；1-[2-(phenylamino)phenyl]trifluoroethanone；alpha,alpha,alpha-Trifluoro-2'-anilinoacetophenone；1-(2-anilinophenyl)-2,2,2-trifluoroethanone
• 化学式: C₁₄H₁₀F₃NO
• 分子量: 265.235
• InChiKey: BDEKCOFUNJUIRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2,2-trifluoro-1-(2-phenylaminophenyl)ethanone 在 三氟乙酸 作用下， 以 氯仿 为溶剂， 反应 72.0h， 以86%的产率得到9-(trifluoromethyl)acridine
  参考文献：
  名称：

  的一种新的合成N-取代о -trifluoroacetylanilines

  摘要：

  一种用于合成N-取代的方法о由N-取代的靛红酸酐与（三氟甲基）三甲基硅烷（Ruppert的-普拉卡什试剂）反应-trifluoroacetylanilines已经研制成功。这种方法提供了容易获得两个N-烷基- о -trifluoroacetylanilines和N-芳基- о高收率-trifluoroacetylanilines。N-芳基-环化о在三氟乙酸-trifluoroacetylanilines给出9- trifluoromethylacridines。

  DOI：

  10.1016/j.jfluchem.2012.07.002
• 作为产物：
  描述：

  N-(2-iodophenyl)-N-phenyltrifluoroacetamide 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以45%的产率得到2,2,2-trifluoro-1-(2-phenylaminophenyl)ethanone
  参考文献：
  名称：

  Intermolecular C−N Addition of Amides and S−N Addition of Sulfinamides to Arynes

  摘要：

  An efficient, mild, transition-metal-free method has been developed for the intermolecular C-N sigma-bond addition of amides and S-N sigma-bond addition of sulfinamides to arynes to form one C-C bond and one heteroatom-carbon bond in one step at room temperature. Evidence for a stepwise mechanism is provided.

  DOI：

  10.1021/ja054079p

文献信息

• Insertion of Benzene Rings into the Amide Bond: One-Step Synthesis of Acridines and Acridones from Aryl Amides
  作者：Didier G. Pintori、Michael F. Greaney

  DOI：10.1021/ol902568x

  日期：2010.1.1

  Insertion of benzene rings into the amide bond using the reactive intermediate benzyne is described. Aromatic amides undergo smooth insertion when treated with O-triflatophenyl silane benzyne precursors, producing versatile aminobenzophenone products in good to excellent yield. The process is entirely metal-free and has been exemplified on the synthesis of biologically active acridones and acridines

  描述了使用反应性中间体苯炔将苯环插入酰胺键。用O-三氟苯基硅烷硅烷苯并炔前体处理后，芳族酰胺会顺利插入，从而以高至优异的收率生产出多种用途的氨基二苯甲酮产品。该方法完全不含金属，并已在生物活性a啶和cr啶的合成中得到了例证。
• Photofunctional optical material comprising fluorine-containing acrylate polymer
  申请人：Ando Yoshito

  公开号：US20070197718A1

  公开（公告）日：2007-08-23

  There is provided the photofunctional optical material which is excellent in an intensity of light emission, light emitting efficiency and/or light amplifying property and also is excellent in processability, for example, easy processing into an optical waveguide device. The photofunctional optical material contains a fluorine-containing acrylate, a polyfunctional acrylate and a rare earth metal compound. There is also provided the composition containing a fluorine-containing acrylate, a polyfunctional acrylate and a rare earth metal compound and is suitable for an optical material.
• Photofunctional Laminated Article
  申请人：Ando Yoshito

  公开号：US20070218289A1

  公开（公告）日：2007-09-20

  There is provided a photofunctional laminated article being excellent in various photofunctionalities, particularly an intensity of light emission, light emitting efficiency and further fluorescence life and light amplifying property. The photofunctional laminated article comprises the transparent substrate (L0), the photofunctional layer (L1) comprising the fluorine-containing polymer (A) and the rare earth metal compound (B) and being formed on the substrate (L0) and the low refractive index layer (L2) formed on the photofunctional layer (L1), and when refractive indices of each layer are assumed to be n(L0), n(L1) and n(L2), the following equation: n(L0)≧n(L1)>n(L2) is satisfied.
• US7378154B2
  申请人：——

  公开号：US7378154B2

  公开（公告）日：2008-05-27
• Intermolecular C−N Addition of Amides and S−N Addition of Sulfinamides to Arynes
  作者：Zhijian Liu、Richard C. Larock

  DOI：10.1021/ja054079p

  日期：2005.9.28

  An efficient, mild, transition-metal-free method has been developed for the intermolecular C-N sigma-bond addition of amides and S-N sigma-bond addition of sulfinamides to arynes to form one C-C bond and one heteroatom-carbon bond in one step at room temperature. Evidence for a stepwise mechanism is provided.