7-benzoyloxy-5-hydroxy-6-methoxy-2-phenyl-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-benzoyloxy-5-hydroxy-6-methoxy-2-phenyl-chromen-4-one
• 英文别名: 7-Benzoyloxy-5-hydroxy-6-methoxy-2-phenyl-chromen-4-on；(5-Hydroxy-6-methoxy-4-oxo-2-phenylchromen-7-yl) benzoate
• 化学式: C₂₃H₁₆O₆
• 分子量: 388.376
• InChiKey: BEJHHRPALCSOIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  千层纸素A 、 苯甲酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 7-benzoyloxy-5-hydroxy-6-methoxy-2-phenyl-chromen-4-one
  参考文献：
  名称：

  Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents

  摘要：

  A series of Oroxylin A derivatives, prepared by alkylation and condensation, were fully characterized by spectroscopic methods. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that acylation of 7-OH group in Oroxylin A significantly enhanced the activity as compared to their parent compound (Oroxylin A).

  DOI：

  10.1016/j.bmcl.2005.05.045

文献信息

• Shah et al., Journal of the Chemical Society, 1936, p. 591
  作者：Shah et al.

  DOI：——

  日期：——