(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-diethylamino-butyric acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-diethylamino-butyric acid methyl ester
• 英文别名: Boc-Ala-Abu(NEt2)-OMe；methyl (2S)-4-(diethylamino)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]butanoate
• 化学式: C₁₇H₃₃N₃O₅
• 分子量: 359.466
• InChiKey: BEZRPMAODZCGKV-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-叔丁氧羰基-L-丙氨酸 在 氰基磷酸二乙酯 、 sodium carbonate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-4-diethylamino-butyric acid methyl ester
  参考文献：
  名称：

  Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides

  摘要：

  The synthesis of a series of novel alpha-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amino acids for the synthesis of cross-linked peptides or dendrimers and conformationally constrained peptides can also be obtained. (C) 1998 Elsevier Science Ltd. ALI rights reserved.

  DOI：

  10.1016/s0040-4039(98)00628-5

文献信息

• Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides
  作者：Paola Ciapetti、André Mann、Angèle Shoenfelder、Maurizio Taddei

  DOI：10.1016/s0040-4039(98)00628-5

  日期：1998.5

  The synthesis of a series of novel alpha-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amino acids for the synthesis of cross-linked peptides or dendrimers and conformationally constrained peptides can also be obtained. (C) 1998 Elsevier Science Ltd. ALI rights reserved.