丙基D-葡糖苷 | 100231-62-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 丙基D-葡糖苷
• 英文名称: Propyl D-glucoside
• 英文别名: 2-(hydroxymethyl)-6-propoxyoxane-3,4,5-triol
• CAS: 100231-62-7
• 化学式: C₉H₁₈O₆
• 分子量: 222.24
• InChiKey: ITOWTHYPYGRTRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• POLYGONAL SCAFFOLD AND MANUFACTURING METHOD THEREOF, AND PROTEIN MODULATOR AND MANUFACTURING METHOD THEREOF
  申请人：NATIONAL TSING HUA UNIVERSITY

  公开号：US20190194590A1

  公开（公告）日：2019-06-27

  A polygonal scaffold includes at least three polyproline II (PPII) helix rods and at least three connectors. Each of the PPII helix rods is composed of a plurality of repeat units represented by Formula (i), and at least one of the PPII helix rods has at least one of hydrogen atoms of at least one of the repeat units being substituted by a first chemical handle for connecting a ligand. Each of the connectors is a divalent organic group, and every two of the PPII helix rods are connected by one of the connectors to form a closed ring.

  一个多边形支架包括至少三根聚脯氨酸Ⅱ（PPII）螺旋棒和至少三个连接器。每根PPII螺旋棒由多个由公式（i）表示的重复单元组成，至少其中一根PPII螺旋棒中的至少一个重复单元的至少一个氢原子被第一化学手柄替代以连接配体。每个连接器是二价有机基团，每两根PPII螺旋棒由一个连接器连接形成闭合环。
• Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
  申请人：Brown Dennis M.

  公开号：US10383847B2

  公开（公告）日：2019-08-20

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutically active agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to therapeutically active agents selected from the group consisting of: (i) indirubin; (ii) an analog of indirubin; (iii) a derivative of indirubin or of an analog of indirubin; and (iv) a pharmaceutical composition comprising indirubin, an analog of indirubin, or a derivative of indirubin or of an analog of indirubin, especially meisoindigo. In particular, the therapeutically active agents selected from the group consisting of: (i) indirubin; (ii) an analog of indirubin; (iii) a derivative of indirubin or of an analog of indirubin; and (iv) a pharmaceutical composition comprising indirubin, an analog of indirubin, or a derivative of indirubin or of an analog of indirubin, especially meisoindigo, are effective Nek9 inhibitors. The active agent, such as meisoindigo, can act as a Nek9 inhibitor. The active agent can be used together with Nek9 inhibitors or agents that inhibit the expression of Nek9.

  本发明描述了通过提高单一疗法的疗效或减少副作用来提高以前受次优治疗性能限制的治疗活性制剂的疗效的方法和组合物。这种方法和组合物特别适用于选自以下组别的治疗活性剂：(i) 靛红素；(ii) 靛红素的类似物；(iii) 靛红素或靛红素类似物的衍生物；(iv) 包含靛红素、靛红素类似物或靛红素或靛红素类似物衍生物的药物组合物，特别是甲异靛。特别是，选自以下组别的治疗活性剂是有效的 Nek9 抑制剂：(i) 靛红素；(ii) 靛红素的类似物；(iii) 靛红素的衍生物或靛红素的类似物；以及 (iv) 由靛红素、靛红素的类似物或靛红素的衍生物或靛红素的类似物，特别是 meisoindigo 组成的药物组合物。活性剂，如 meisoindigo，可作为 Nek9 抑制剂。活性剂可与 Nek9 抑制剂或抑制 Nek9 表达的制剂一起使用。
• EXTERNAL SKIN AGENT COMPRISING MODIFIED CLAY FOR PREVENTING INFLAMMATION
  申请人：Pola Chemical Industries Inc.

  公开号：EP1846010B1

  公开（公告）日：2011-08-03
• Alkylpolyglycosides useful as stabilizers for pur foams
  申请人：Mager Michael

  公开号：US20080070999A1

  公开（公告）日：2008-03-20

  The invention relates to polyurethane foam forming compositions which produce hydrophilicized polyurethane foams, in particular foams which are suitable as wound dressing foams. These compositions comprise (I) a polyurethane dispersion and (II) specific additives including one or more alkylpolyglycoside. The process of producing these foams comprises frothing and drying these polyurethane foam forming compositions.
• FAST-CURING ALKOXYSILANE SPRAY FOAMS
  申请人：Schönberger Jan

  公开号：US20140234283A1

  公开（公告）日：2014-08-21

  The present invention relates to an isocyanate-free multicomponent system, especially for production of foams for medical products such as wound dressings, comprising at least two separate components, the first component comprising at least one alkoxysilane-terminated prepolymer and the second component an aqueous component, and the aqueous component having a pH of 4.0 to 9.5 at 20 DEG C.

表征谱图