2-phenyl-4-({[(1S)-1-phenylpropyl]amino}carbonyl)quinolin-3-yl methanesulfonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-phenyl-4-({[(1S)-1-phenylpropyl]amino}carbonyl)quinolin-3-yl methanesulfonate
• 英文别名: [2-phenyl-4-[[(1S)-1-phenylpropyl]carbamoyl]quinolin-3-yl] methanesulfonate
• 化学式: C₂₆H₂₄N₂O₄S
• 分子量: 460.554
• InChiKey: BLWLOUSTXZIEHT-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  93.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲基磺酰氯 、 (-)-(S)-N-(alpha-乙基苄基)-3-羟基-2-苯基喹啉-4-羧酰胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以79%的产率得到2-phenyl-4-({[(1S)-1-phenylpropyl]amino}carbonyl)quinolin-3-yl methanesulfonate
  参考文献：
  名称：

  WO2006/137789

  摘要：

  公开号：

文献信息

• Quinoline 3-Sulfonate Esters as Nk3 Receptor Modulators
  申请人：Simpson Thomas R.

  公开号：US20080194622A1

  公开（公告）日：2008-08-14

  Compounds of Formula I wherein R 1 , A, R 2 , R 3 , R 4 , R 5 n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
• Method For Treating Or Preventing Hot Flushes
  申请人：IMPERIAL INNOVATIONS LIMITED

  公开号：US20160220555A1

  公开（公告）日：2016-08-04

  The invention provides a neurokinin 3 receptor (NKR3) antagonist for use in the treatment, prevention or amelioration of hot flushes in a human subject, for example a menopausal woman or a patient undergoing cancer therapy which affects secretion of sex steroids. The invention also provides a NKR3 antagonist together with a further active agent, and a composition and a kit comprising a NKR3 antagonist and a further active agent. The invention further provides a NKR3 agonist or exogenous NKB for the induction of hot flushes in a human subject.
• [EN] METHOD FOR TREATING OR PREVENTING HOT FLUSHES<br/>[FR] PROCÉDÉ POUR TRAITER OU PRÉVENIR DES BOUFFÉES DE CHALEUR
  申请人：IMP INNOVATIONS LTD

  公开号：WO2015033163A1

  公开（公告）日：2015-03-12

  The invention provides a neurokinin 3 receptor (NKR3) antagonist for use in the treatment, prevention or amelioration of hot flushes in a human subject, for example a menopausal woman or a patient undergoing cancer therapy which affects secretion of sex steroids. The invention also provides a NKR3 antagonist together with a further active agent, and a composition and a kit comprising a NKR3 antagonist and a further active agent. The invention further provides a NKR3 agonist or exogenous NKB for the induction of hot flushes in a human subject.
• WO2006/137789
  申请人：——

  公开号：——

  公开（公告）日：——