3-anilino-quinolin-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-anilino-quinolin-2-ol
• 英文别名: 3-Anilino-chinolin-2-ol；3-anilino-1H-quinolin-2-one
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: BOVWTUKHEGQIEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-anilino-quinolin-2-ol 在 copper diacetate 、 palladium diacetate 、 三甲基乙酸 作用下， 反应 4.0h， 以91%的产率得到5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one
  参考文献：
  名称：

  Synthesis of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones via microwave-assisted base-free intramolecular cross dehydrogenative coupling

  摘要：

  A microwave-assisted base-free intramolecular cross dehydrogenative coupling (CDC) of 3-aniline substituted coumarins and quinolinones have been developed. A broad range of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones can be easily afforded in good to high yields (up to 93%) under palladium catalysis. The method is among the most straightforward and convenient ways to access these fused polyheterocycles. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2018.11.066
• 作为产物：
  描述：

  1,2-二苯肼 在 甲醇 、 氢氧化钾 作用下， 生成 3-anilino-quinolin-2-ol
  参考文献：
  名称：

  Diels; Reese, Justus Liebigs Annalen der Chemie, 1934, vol. 511, p. 168,177

  摘要：

  DOI：

文献信息

• Use of aliginate oligomers and CFTR modulators in treatment of conditions associated with CFTR dysfunction
  申请人：AlgiPharma AS

  公开号：US10751363B2

  公开（公告）日：2020-08-25

  A method is for the treatment of a condition in a subject, which arises from or is associated with CFTR dysfunction. The method includes administering to the subject an effective amount of a CFTR modulator together with an effective amount of an alginate oligomer. The condition can be cystic fibrosis (CF), non-compound CFTR gene mutation heterozygosity, abnormal mucus clearance in the respiratory tract and/or breathing difficulties resulting from chronic particulate inhalation, COPD, chronic bronchitis, emphysema, bronchiectasis, asthma or chronic sinusitis, or a complication of any of these.

  一种用于治疗受试者因 CFTR 功能障碍引起或与之相关的疾病的方法。该方法包括向受试者施用有效量的 CFTR 调节剂和有效量的藻酸盐低聚物。病症可以是囊性纤维化（CF）、非复合 CFTR 基因突变杂合子、呼吸道粘液清除异常和/或慢性微粒吸入导致的呼吸困难、慢性阻塞性肺病、慢性支气管炎、肺气肿、支气管扩张、哮喘或慢性鼻窦炎，或上述任何病症的并发症。
• USE OF ALGINATE OLIGOMERS AND CFTR MODULATORS IN THE TREATMENT OF CONDITIONS ASSOCIATED WITH CFTR DYSFUNCTION
  申请人：ALGIPHARMA AS

  公开号：EP3273995A1

  公开（公告）日：2018-01-31
• COMBINED USE OF ALGINATE OLIGOMERS AND THE CFTR MODULATOR LUMACAFTOR IN THE TREATMENT OF CONDITIONS ASSOCIATED WITH CFTR DYSFUNCTION
  申请人：ALGIPHARMA AS

  公开号：EP3273995B1

  公开（公告）日：2021-07-14
• USE OF ALGINATE OLIGOMERS TO ENHANCE THE TRANSLOCATION OF MICRO/NANOPARTICLES ACROSS MUCUS LAYERS
  申请人：ALGIPHARMA AS

  公开号：EP3768323A1

  公开（公告）日：2021-01-27
• ALGINATE OLIGOMERS FOR THE TREATMENT OR PREVENTION OF MICROBIAL OVERGROWTH IN THE INTESTINAL TRACT
  申请人：AlgiPharma AS

  公开号：US20190117683A1

  公开（公告）日：2019-04-25

  The invention provides a method for the treatment or prevention of microbial overgrowth in at least part of the intestinal tract of a subject, said method comprising administering an effective amount of an alginate oligomer to a subject in need thereof. Also provided is an alginate oligomer for use in the treatment or prevention of microbial overgrowth in at least part of the intestinal tract of a subject and a product containing an alginate oligomer and further pharmaceutical for the treatment of intestinal microbial overgrowth and/or a CFTR modulator as a combined preparation for separate, simultaneous or sequential use in the treatment or prevention of microbial overgrowth in at least part of the intestinal tract of a subject.