[Ce(5,7-dichloro-8-hydroxylquinoline)₄]

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [Ce(5,7-dichloro-8-hydroxylquinoline)₄]
• 英文别名: Cerium(4+);5,7-dichloroquinolin-8-olate；cerium(4+);5,7-dichloroquinolin-8-olate
• 化学式: C₃₆H₁₆CeCl₈N₄O₄
• 分子量: 992.291
• InChiKey: FHBLKUBIMLFXSS-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  10.46
• 重原子数：
  53
• 可旋转键数：
  0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  5,7-二氯-8-羟基喹啉 、 cerium(III) chloride heptahydrate 在 sodium hydroxide 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 72.0h， 以75%的产率得到[Ce(5,7-dichloro-8-hydroxylquinoline)₄]
  参考文献：
  名称：

  High antitumor activity of 5,7-dihalo-8-quinolinolato cerium complexes

  摘要：

  Three cerium complexes: [Ce(ClQ)(4)] (1) (H-ClQ = 5,7-dichloro-8-hydroxylquinoline), [Ce(ClIQ)(4)]center dot CH2Cl2 center dot 0.5H(2)O (2) (H-ClIQ = 5-chloro-7-iodo-8-hydroxylquinoline) and [Ce-2(BrQ)(4)(H-BrQ)(H2O)(3)Cl-2]center dot 1.5H(2)O (3) (H-BrQ = 5,7-dibromo-8-hydroxylquinoline) were synthesized. The structures of 1 and 2 are mononuclear whereas 3 has a binuclear structure. Compared with the H-ClQ H-CIIQ and H-BrQ complexes 1-3 exhibited significantly higher cytotoxicity (IC50 = 0.09-5.23 mu M) to SK-OV-3 and BEL-7404, 1 and 2 exhibited higher cytotoxicity to NCI-H460. Most the complexes and ligands exhibited higher cytotoxicity than cisplatin. Complexes 1-3 are much more sensitive to SK-OV-3 than to human normal liver cell HL-7702. Their antitumor activities were achieved through cell apoptosis and arrest at G0/G1-phase. Studies on the binding properties of 1-3 to DNA indicate that intercalation is the most probable binding mode. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.08.007

文献信息

• High antitumor activity of 5,7-dihalo-8-quinolinolato cerium complexes
  作者：Zhen-Feng Chen、Jian-Hua Wei、Yan-Cheng Liu、Mei Liu、Yun-Qiong Gu、Ke-Bin Huang、Meng Wang、Hong Liang

  DOI：10.1016/j.ejmech.2013.08.007

  日期：2013.10

  Three cerium complexes: [Ce(ClQ)(4)] (1) (H-ClQ = 5,7-dichloro-8-hydroxylquinoline), [Ce(ClIQ)(4)]center dot CH2Cl2 center dot 0.5H(2)O (2) (H-ClIQ = 5-chloro-7-iodo-8-hydroxylquinoline) and [Ce-2(BrQ)(4)(H-BrQ)(H2O)(3)Cl-2]center dot 1.5H(2)O (3) (H-BrQ = 5,7-dibromo-8-hydroxylquinoline) were synthesized. The structures of 1 and 2 are mononuclear whereas 3 has a binuclear structure. Compared with the H-ClQ H-CIIQ and H-BrQ complexes 1-3 exhibited significantly higher cytotoxicity (IC50 = 0.09-5.23 mu M) to SK-OV-3 and BEL-7404, 1 and 2 exhibited higher cytotoxicity to NCI-H460. Most the complexes and ligands exhibited higher cytotoxicity than cisplatin. Complexes 1-3 are much more sensitive to SK-OV-3 than to human normal liver cell HL-7702. Their antitumor activities were achieved through cell apoptosis and arrest at G0/G1-phase. Studies on the binding properties of 1-3 to DNA indicate that intercalation is the most probable binding mode. (C) 2013 Elsevier Masson SAS. All rights reserved.