4,6,4',6'-di-O-(4-allyloxybenzylidene)-α,α-D-trehalose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,6,4',6'-di-O-(4-allyloxybenzylidene)-α,α-D-trehalose
• 英文别名: (4aR,6R,7R,8R,8aS)-6-[[(4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(4-prop-2-enoxyphenyl)-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-2-(4-prop-2-enoxyphenyl)-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-7,8-diol
• 化学式: C₃₂H₃₈O₁₃
• 分子量: 630.646
• InChiKey: QTWKGYRJKWNXHD-FRXIEALQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  45
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  164
• 氢给体数：
  4
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  海藻糖 、 4-烯丙氧基苯甲醛 在 Amberlyst 15 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 48.0h， 以53%的产率得到4,6,4',6'-di-O-(4-allyloxybenzylidene)-α,α-D-trehalose
  参考文献：
  名称：

  Novel acid-degradable and thermo-sensitive poly( N -isopropylacrylamide) hydrogels cross-linked by α,α-trehalose diacetals

  摘要：

  New trehalose-containing hydrogels and the first hydrogels cross-linked by mono- or disaccharide acetals that are degradable in acidic medium were designed and synthesized. The cross-linking agent was obtained in acetalization reaction of trehalose with x-allyloxybenzaldehyde in which diallyl compounds were formed and used afterward in free radical copolymerization with N-isopropylacrylamide (NIPAAm) to provide thermo-sensitive hydrogels. Depending on the trehalose diacetal isomer and solvent system used in copolymerization, as well the degree of network cross-linking, these hydrogels differed in morphology, swelling and deswelling behavior and time of degradation. Compared with conventional PNIPAAm hydrogels they are degradable what makes them good materials for biomedical applications. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2014.10.032