9-ethyl-3-(1H-imidazo[4,5-c]pyridin-2-yl)-9H-carbazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-ethyl-3-(1H-imidazo[4,5-c]pyridin-2-yl)-9H-carbazole
• 英文别名: 9-ethyl-3-(3H-imidazo[4,5-c]pyridin-2-yl)carbazole
• 化学式: C₂₀H₁₆N₄
• 分子量: 312.374
• InChiKey: BSEFEFWNWWAMGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-二氨基吡啶 、 N-乙基咔唑-3-甲醛 在 ammonium hydroxide 作用下， 以 硝基苯 为溶剂， 反应 24.0h， 以to afford the title compound 5A (94 mg)的产率得到9-ethyl-3-(1H-imidazo[4,5-c]pyridin-2-yl)-9H-carbazole
  参考文献：
  名称：

  NPY-5 antagonists

  摘要：

  本发明提供了一种具有式（IA）的NPY-5受体拮抗剂，同时提供了用于治疗受上述NPY-5受体拮抗剂调节的疾病、状况和/或疾病的方法和药物组合物。

  公开号：

  US20040122046A1

文献信息

• Structure–activity relationships in a series of NPY Y5 antagonists: 3-amido-9-ethylcarbazoles, core-modified analogues and amide isosteres
  作者：Marlys Hammond、Richard L. Elliott、Melissa L. Gillaspy、David C. Hager、Richard F. Hank、Janet A. LaFlamme、Robert M. Oliver、Paul A. DaSilva-Jardine、Ralph W. Stevenson、Christine M. Mack、James V. Cassella

  DOI：10.1016/s0960-894x(03)00329-9

  日期：2003.6

  Beginning with carbazole la, the amide and alkyl substituents were optimized to maintain potency while adding solubilizing groups. Efforts to replace the 3-amino-9-ethylcarbazole core, a known carcinogen, used the SAR generated in the carbazole series for guidance and led to the synthesis of a number of core-modified analogues. In addition, an isosteric series, in which the amide was replaced with an imidazole, was prepared. Two potent new series lacking the putative toxicophore were identified from these endeavors. (C) 2003 Elsevier Science Ltd. All rights reserved.
• CARBAZOLE DERIVATIVES AND THEIR USE AS NPY-5 ANTAGONISTS
  申请人：Pfizer Products Inc.

  公开号：EP1575934A1

  公开（公告）日：2005-09-21
• JP2006511530A
  申请人：——

  公开号：JP2006511530A

  公开（公告）日：2006-04-06
• US6949564B2
  申请人：——

  公开号：US6949564B2

  公开（公告）日：2005-09-27
• [EN] CARBAZOLE DERIVATIVES AND THEIR USE AS NPY-5 ANTAGONISTS<br/>[FR] DERIVES DE CARBAZOLE ET LEURS UTILISATIONS EN TANT QU'ANTAGONISTES DE NPY-5
  申请人：PFIZER PROD INC

  公开号：WO2004055002A1

  公开（公告）日：2004-07-01

  The present invention provides NPY-5 receptor antagonists having a Formula (IA). Methods and pharmaceutical compositions useful for treating diseases, conditions and/or disorders modulated by the above NPY-5 receptor antagonists are also provided.