carbazole spermine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: carbazole spermine
• 英文别名: N-[4-[4-(4-aminobutylamino)butylamino]butyl]carbazole-9-carboxamide
• 化学式: C₂₅H₃₇N₅O
• 分子量: 423.602
• InChiKey: ZIOSCDPLBZCHSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  84.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  C₃₇H₄₃N₇O₉S₂ 在 potassium carbonate 、 苯硫酚 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 carbazole spermine
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers

  摘要：

  We have developed a new class of N-methyl-D-aspartate (NMDA) channel blockers having a conjugate structure that consists of a nitrogenous heterocyclic head and a tetraamine tail. Among them, dihydrodibenzazepine-homospermine conjugate (8) exhibited potent antagonistic activity at NR1/NR2A or NR1/NR2B NMDA subtype receptors compared with the lead compound, AQ343 (1), or memantine, as well as weak cytotoxicity. Its superior biological profiles compared with known compounds point to its potential use as therapeutic agents for neurological disorders. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.069

文献信息

• COMPOUNDS BLOCKING THE NMDA RECEPTOR CHANNEL AND PHARMACEUTICAL AGENT USING THE SAME
  申请人：National University Corporation Chiba University

  公开号：EP2039354B1

  公开（公告）日：2011-06-29
• Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers
  作者：Hiromitsu Takayama、Yuichi Yaegashi、Mariko Kitajima、Xia Han、Kazuhiro Nishimura、Shigeru Okuyama、Kazuei Igarashi

  DOI：10.1016/j.bmcl.2007.06.069

  日期：2007.9

  We have developed a new class of N-methyl-D-aspartate (NMDA) channel blockers having a conjugate structure that consists of a nitrogenous heterocyclic head and a tetraamine tail. Among them, dihydrodibenzazepine-homospermine conjugate (8) exhibited potent antagonistic activity at NR1/NR2A or NR1/NR2B NMDA subtype receptors compared with the lead compound, AQ343 (1), or memantine, as well as weak cytotoxicity. Its superior biological profiles compared with known compounds point to its potential use as therapeutic agents for neurological disorders. (c) 2007 Elsevier Ltd. All rights reserved.