β-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-glucose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-glucose
• 英文别名: Gal(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc(b1-4)GlcNAc；N-[(3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-acetamido-5-[(2S,3R,4R,5S,6R)-3-acetamido-5-[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• 化学式: C₃₈H₆₄N₄O₂₆
• 分子量: 992.937
• InChiKey: VTWLERFXACNYBI-LLEOTHBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.2
• 重原子数：
  68
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  463
• 氢给体数：
  17
• 氢受体数：
  26

反应信息

• 作为产物：
  描述：

  尿苷(5')二氢二磷酰(1)-alpha-D-葡萄糖 、 N,N',N'',N'''-tetraacetylchitotetraose 在 manganese(ll) chloride cacodylate buffer 作用下， 反应 48.0h， 以81%的产率得到β-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-glucose
  参考文献：
  名称：

  Enzymatic Galactosylation of Cello‐ and Chito‐Oligomers

  摘要：

  Terminal galactosylations of cello- and chito-oligomers are studied employing galactosyltransferase with and without alpha-lactalbumin. The lactose synthase complex allows just for galactosylation of cellobiose in lower yield but not for higher cello-oligomers. In contrast, the affinity in galactosylation of chito-oligomers increases with higher members to reach the maximum at chitohexaose with only a 30% reduction in transfer rate. In addition to kinetic data, preparative studies with a number of acceptor substrates gave galactosylated oligosaccharides in high yields.[GRAPHICS]

  DOI：

  10.1080/07328300802030779

文献信息

• Enzymatic Galactosylation of Cello‐ and Chito‐Oligomers
  作者：Harald Streicher、Oliver Scheel、Joachim Thiem

  DOI：10.1080/07328300802030779

  日期：2008.5

  Terminal galactosylations of cello- and chito-oligomers are studied employing galactosyltransferase with and without alpha-lactalbumin. The lactose synthase complex allows just for galactosylation of cellobiose in lower yield but not for higher cello-oligomers. In contrast, the affinity in galactosylation of chito-oligomers increases with higher members to reach the maximum at chitohexaose with only a 30% reduction in transfer rate. In addition to kinetic data, preparative studies with a number of acceptor substrates gave galactosylated oligosaccharides in high yields.[GRAPHICS]