1-(((2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)ethyl isobutyrate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 1-(((2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)ethyl isobutyrate
• 英文别名: 1-[[(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl]oxy]ethyl 2-methylpropanoate
• 化学式: C₂₁H₂₄O₈
• 分子量: 404.417
• InChiKey: HCQJOOCXAYJJLH-JWOXJJEYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  表儿茶素 在 palladium 10% on activated carbon 、 氢气 、 sodium hydride 、 potassium carbonate 作用下， 以 甲醇 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.25h， 生成 1-(((2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)ethyl isobutyrate
  参考文献：
  名称：

  US2014/256741

  摘要：

  公开号：

文献信息

• Reversing baldness through follicle regeneration
  申请人：Postrel Richard

  公开号：US11331300B2

  公开（公告）日：2022-05-17

  This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

  本发明通过将休眠毛囊从雄性激素诱导的冬眠期震回到活跃的头发生长期，从而逆转男性型秃发。本发明集成了两种功能：1）阻止使毛囊处于休止期/冬眠期的化合物的合成；2）刺激毛囊活动周期中使毛发生长期/新生期活跃的化合物的合成。一个优选的实施方案包括：一种酶抑制剂，可阻止睾酮向双氢睾酮（DHT）的转化；一种类黄酮，可同时增加前列腺素 D2 替代物的合成；以及一种精选的大麻素化合物，可刺激毛囊恢复正常的生长周期。这种新颖的三联疗法能使毛囊恢复正常的循环过程，只要保持这种恢复平衡，就能保持这些恢复特性。
• FLAVONOID COMPOUNDS
  申请人：Cardero Therapeutics, Inc.

  公开号：EP2739613A2

  公开（公告）日：2014-06-11
• US20140256741A1
  申请人：——

  公开号：US20140256741A1

  公开（公告）日：2014-09-11
• Reversal of Baldness in Men and Women through Cannabinoid Receptor Activation
  申请人：Postrel Richard

  公开号：US20220249434A1

  公开（公告）日：2022-08-11

  This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D 2 , and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.
• US9187448B2
  申请人：——

  公开号：US9187448B2

  公开（公告）日：2015-11-17