1-(2-furanyl)-3-(3-pyridinyl)-2-propene-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-furanyl)-3-(3-pyridinyl)-2-propene-1-one
• 英文别名: (E)-1-furan-2-yl-3-pyridin-3-yl-propenone；(E)-1-(furan-2-yl)-3-pyridin-3-ylprop-2-en-1-one
• 化学式: C₁₂H₉NO₂
• 分子量: 199.209
• InChiKey: LVVLNTUVIGKOGB-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-furanyl)-3-(3-pyridinyl)-2-propene-1-one 、 1-[2-氧-2-(2-吡啶基)乙基]碘化吡啶 在 乙酸铵 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship

  摘要：

  Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10-20 showed significant topoisomerase I or II inhibitory activities, and 21-26 showed considerable cytotoxicities against several human cancer cell lines. Structure-activity relationship study indicates that 4-pyridine at 6-position of central pyridine plays a key role in biological activity. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.04.047
• 作为产物：
  描述：

  3-吡啶甲醛 、 2-乙酰基呋喃 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 1-(2-furanyl)-3-(3-pyridinyl)-2-propene-1-one
  参考文献：
  名称：

  2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship

  摘要：

  Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10-20 showed significant topoisomerase I or II inhibitory activities, and 21-26 showed considerable cytotoxicities against several human cancer cell lines. Structure-activity relationship study indicates that 4-pyridine at 6-position of central pyridine plays a key role in biological activity. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.04.047

文献信息

• Microwave-Assisted Convenient Synthesis of<i>α</i>,<i>β</i>-Unsaturated Esters and Ketones<i>via</i>Aldol-Adduct Elimination
  作者：Pathi Suman、Rayala Nageswara Rao、Bhimapaka China Raju

  DOI：10.1002/hlca.201200526

  日期：2013.8

  Various fluorinated 3‐oxo ester/1,3‐diketones were reacted with carbonyl compounds, in presence of piperidine and under microwave irradiation, to afford (E)‐α,β‐unsaturated esters and ketones in good yields. The systematic study reveals that the reaction proceeded through the formation of aldol adduct. The method provides a new and simple way for C,C bond formations.

  在哌啶存在下并在微波辐射下，将各种氟化的3-氧代酯/ 1,3-二酮与羰基化合物反应，得到高收率的（E）-α，β-不饱和酯和酮。系统研究表明反应是通过醛醇加合物的形成而进行的。该方法为C，C键的形成提供了一种新的简单方法。
• Calcium uptake inhibitors
  申请人：MERRELL PHARMACEUTICALS INC.

  公开号：EP0476646A1

  公开（公告）日：1992-03-25

  This invention relates to 1-aryl-3-pyridinyl-2-propene-1-ones and pharmaceutical compositions containing these compounds as active ingredients useful as calcium uptake inhibitors in leukocytes and thrombocytes and the process of their preparation.

  本发明涉及 1-芳基-3-吡啶基-2-丙烯-1-酮和含有这些化合物作为活性成分的药物组合物，可作为白细胞和血小板的钙摄取抑制剂，及其制备工艺。
• [EN] PYRIDINE DERIVATIVES<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：NOVARTIS AG

  公开号：WO2009087212A3

  公开（公告）日：2009-09-24
• VIEWEG, H.;HANFELD, VERA;LEISTHER, S.;WAGNER, G., PHARMAZIE, 44,(1989) N, C. 639-640
  作者：VIEWEG, H.、HANFELD, VERA、LEISTHER, S.、WAGNER, G.

  DOI：——

  日期：——
• JPH06271540A
  申请人：——

  公开号：JPH06271540A

  公开（公告）日：1994-09-27