8-(4-fluorobenzyloxy)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(4-fluorobenzyloxy)quinoline
• 英文别名: 8-[(4-Fluorophenyl)methoxy]quinoline
• 化学式: C₁₆H₁₂FNO
• 分子量: 253.276
• InChiKey: JAAIESMICFNIBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  8-羟基喹啉 、 alkaline earth salt of/the/ methylsulfuric acid 在 四丁基溴化铵 、 potassium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 以74%的产率得到8-(4-fluorobenzyloxy)quinoline
  参考文献：
  名称：

  Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

  摘要：

  A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 mu g/mL which was comparable to 8-hydroxyquinoline (2.5 mu g/mL) and terbinafine (1.25 mu g/mL) against A. niger.

  DOI：

  10.1007/s00044-014-1217-4

文献信息

• [EN] NOVEL 6-PHENYLPHENANTHRIDINES<br/>[FR] NOUVELLES 6-PHENYLPHENANTHRIDINES
  申请人：ALTANA PHARMA AG

  公开号：WO2005012253A1

  公开（公告）日：2005-02-10

  Compounds of a certain formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R7 and R8 have the meanings indicated in the description, are novel effective PDE4 inhibitors.

  具有以下含义的化合物(I)，其中R1、R2、R3、R31、R4、R5、R51、R6、R7和R8的含义如说明书所示，是新型有效的PDE4抑制剂。
• Azole derivatives of naphthaleone oxime esters
  申请人：UNIROYAL CHEMICAL COMPANY, Inc.

  公开号：EP0351979A2

  公开（公告）日：1990-01-24

  The invention relates to compounds useful as fungicides and plant growth regulants represented by the formula in which: R is a substituent or a group of substituents representing halogen, low alkyl of 1 to 6 carbon atoms, phenyl, substituted phenyl, phenoxy, substituted phenoxy, naphthyl, nitro, cyano, low alkoxy, alkoxycarbonyl, or trifluoromethyl; X is single bond, oxygen, sulfur or sulfonyl; G is CH or nitrogen atom; m is an integer from 1 to 4 and a process of making the compound.

  本发明涉及可用作杀真菌剂和植物生长调节剂的化合物，其式如下 其中 R 是取代基或取代基组，代表卤素、1-6 个碳原子的低级烷基、苯基、取代苯基、苯氧基、取代苯氧基、萘基、硝基、氰基、低级烷氧基、烷氧羰基或三氟甲基； X 是单键、氧、硫或磺酰基； G 是 CH 或氮原子 m 是 1 至 4 的整数，以及制造该化合物的工艺。
• Method of preparing a composition containing hygromycin A and epi-hygromycin
  申请人：Pfizer Products Inc.

  公开号：EP1369490A1

  公开（公告）日：2003-12-10

  A method of preparing a composition containing hygromycin A and epi-hygromycin, wherein the ratio of hygromycin A to epi-hygromycin is at least 10:1, which comprises fermenting Streptomyces hygroscopicus in media having a pH less than 6.9 at a temeperature ranging from 25°C to 35°C.

  一种制备含百日咳霉素 A 和表-百日咳霉素的组合物的方法，其中百日咳霉素 A 与表-百日咳霉素的比例至少为 10:1，该方法包括在 pH 值小于 6.9 的培养基中，在 25°C 至 35°C 的温度范围内发酵吸湿链霉菌。
• Dérivés d'indénoindolones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
  申请人：Les Laboratoires Servier

  公开号：EP1266887B1

  公开（公告）日：2005-08-17
• HYGROMYCIN A DERIVATIVES
  申请人：Pfizer Products Inc.

  公开号：EP1075483B1

  公开（公告）日：2003-12-03