N,N,3-trimethyl-hexanamide | 959055-27-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N,3-trimethyl-hexanamide
• 英文别名: 4-Methylheptanamide, N,N-dimethyl-；N,N,4-trimethylheptanamide
• CAS: 959055-27-7
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: VGSBHBNHNJAJJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  12.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  2-甲基-1-戊醇 、 N,N-二甲基乙酰胺 在 C₂₉H₅₅IrN₃P₂⁽¹⁺⁾*Cl^(1-) 、 potassium tert-butylate 作用下， 以 甲苯 为溶剂， 反应 15.0h， 以73%的产率得到N,N,3-trimethyl-hexanamide
  参考文献：
  名称：

  Iridium-Catalyzed Selective α-Alkylation of Unactivated Amides with Primary Alcohols

  摘要：

  The first a-alkylation of unactivated amides with primary alcohols is described. An effective and robust iridium pincer complex has been developed for selective alpha-alkylation of tertiary and secondary acetamides involving a "borrowing hydrogen" methodology. The method is compatible with alcohols bearing various functional groups. This presents a convenient and environmentally benign protocol for alpha-alkylation of amides.

  DOI：

  10.1021/ol400360g

文献信息

• ANTIBODIES, COMPOUNDS AND SCREENS FOR IDENTIFYING AND TREATING CACHEXIA OR PRE-CACHEXIA
  申请人：The Broad Institute Inc.

  公开号：EP3822291A1

  公开（公告）日：2021-05-19

  The invention provides therapeutic, engineered protein/peptide compositions comprising e.g., RAGE antibodies, T-cell receptors to target a RAGE receptor (including soluble forms thereof) directly and/or via differential competition with one or more pre-cachexia and/or cachexia-associated RAGE ligands or markers.

  本发明提供了具有治疗作用的工程化蛋白质/肽组合物，这些组合物由 RAGE 抗体、T 细胞受体等组成，可直接靶向 RAGE 受体（包括其可溶形式）和/或通过与一种或多种恶性肿瘤前和/或恶性肿瘤相关的 RAGE 配体或标记物的差异竞争靶向 RAGE 受体。
• IMIDAZOPYRIDINES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
  申请人：Janssen Sciences Ireland UC

  公开号：EP2651934B1

  公开（公告）日：2017-02-22
• Iridium-Catalyzed Selective α-Alkylation of Unactivated Amides with Primary Alcohols
  作者：Le Guo、Yinghua Liu、Wubing Yao、Xuebing Leng、Zheng Huang

  DOI：10.1021/ol400360g

  日期：2013.3.1

  The first a-alkylation of unactivated amides with primary alcohols is described. An effective and robust iridium pincer complex has been developed for selective alpha-alkylation of tertiary and secondary acetamides involving a "borrowing hydrogen" methodology. The method is compatible with alcohols bearing various functional groups. This presents a convenient and environmentally benign protocol for alpha-alkylation of amides.