L-Leu-Thz

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: L-Leu-Thz
• 英文别名: 2-[(1S)-1-amino-3-methylbutyl]-1,3-thiazole-4-carboxylic acid
• 化学式: C₉H₁₄N₂O₂S
• 分子量: 214.288
• InChiKey: VPOUHXIFZIYTIR-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Boc-Leu-ψ(CSNH2) 在 三氟乙酸 作用下， 以 乙醇 、 苯甲醚 为溶剂， 反应 4.0h， 生成 L-Leu-Thz
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity in Vitro of New Amino Acids and Peptides Containing Thiazole and Oxazole Moieties

  摘要：

  2-(Pyrrolidinyl)thiazole-4-carboxylic acid 5d, 2-(1-aminoalkyl)thiazole-4-carboxamides and hydrazides 8, 10 have been synthesized using alanine, valine, and proline as educts. In addition oxazole amino acids derived from leucine 20a and alanine 20b and some peptides 13, 14, 16 containing the 5-ring heterocyclic backbone modifications have been prepared. The thiazole and oxazole containing amino acids and peptides showed moderate antibacterial activity in vitro against various Gram-positive (Staphylococcus aureus, Bacillus cereus, etc.) and Gram-negative (Escherichia coli, Proteus vulgar is, etc.) bacteria, fungi (Candida albicans), and yeast (Saccharomyces cerevisae, etc.).

  DOI：

  10.1002/(sici)1521-4184(19999)332:9<297::aid-ardp297>3.0.co;2-#

文献信息

• Synthesis and Antimicrobial Activity <i>in Vitro</i> of New Amino Acids and Peptides Containing Thiazole and Oxazole Moieties
  作者：Mincho Stanchev、Svoboda Tabakova、Georgi Videnov、Evgeny Golovinsky、Guenther Jung

  DOI：10.1002/(sici)1521-4184(19999)332:9<297::aid-ardp297>3.0.co;2-#

  日期：1999.9

  2-(Pyrrolidinyl)thiazole-4-carboxylic acid 5d, 2-(1-aminoalkyl)thiazole-4-carboxamides and hydrazides 8, 10 have been synthesized using alanine, valine, and proline as educts. In addition oxazole amino acids derived from leucine 20a and alanine 20b and some peptides 13, 14, 16 containing the 5-ring heterocyclic backbone modifications have been prepared. The thiazole and oxazole containing amino acids and peptides showed moderate antibacterial activity in vitro against various Gram-positive (Staphylococcus aureus, Bacillus cereus, etc.) and Gram-negative (Escherichia coli, Proteus vulgar is, etc.) bacteria, fungi (Candida albicans), and yeast (Saccharomyces cerevisae, etc.).