乙酮,1-(4-乙基-3-甲基苯基)-(9CI) | 118097-50-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 乙酮,1-(4-乙基-3-甲基苯基)-(9CI)
• 中文别名: 1-(4-乙基-3-甲基苯基)乙酮
• 英文名称: 4-ethyl-3-methylacetophenone
• 英文别名: Ethanone, 1-(4-ethyl-3-methylphenyl)-；1-(4-ethyl-3-methylphenyl)ethanone
• CAS: 118097-50-0
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: UZOHPBKCNXJSOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-ethyl-5-methyl-2(H)-pyranone 、 3-丁炔-2-酮 反应 24.0h， 生成 1-(3-乙基-4-甲基苯基)乙酮 、 乙酮,1-(4-乙基-3-甲基苯基)-(9CI)
  参考文献：
  名称：

  Regioselectivity in the diels-alder reactions of α-pyrones with alkynes

  摘要：

  DOI：

  10.1016/s0040-4020(01)90334-5

文献信息

• 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS
  申请人：Sugimoto Tomohiro

  公开号：US20110237784A1

  公开（公告）日：2011-09-29

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae , or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种新型的10a-azalide化合物，其在10a-和12-位置交联，化学式如下，并且对于Hemophilus influenzae，或者对红霉素产生耐药性的细菌（例如耐药性肺炎球菌和链球菌）具有有效性。
• Novel organic electroluminescent compounds and organic electroluminescent device using the same
  申请人：Gracel Display Inc.

  公开号：EP2055710A1

  公开（公告）日：2009-05-06

  The present invention relates to novel organic electroluminescent compounds exhibiting high luminous efficiency, and organic electroluminescent devices comprising the same. The organic electroluminescent compounds according to the invention are represented by Chemical Formula (1):

  本发明涉及具有高发光效率的新型有机电致发光化合物，以及由其组成的有机电致发光器件。根据本发明的有机电致发光化合物由化学式（1）表示：
• Novel red electroluminescent compounds and organic electroluminescent device using the same
  申请人：Gracel Display Inc.

  公开号：EP2060579A1

  公开（公告）日：2009-05-20

  The present invention relates to novel organic electroluminescent compounds exhibiting high luminous efficiency, and organic electroluminescent devices comprising the same. The organic electroluminescent compounds according to the invention are represented by Chemical Formula (1):

  本发明涉及具有高发光效率的新型有机电致发光化合物，以及由其组成的有机电致发光器件。根据本发明的有机电致发光化合物由化学式（1）表示：
• Piperidine and piperazine derivatives as autotaxin inhibitors
  申请人：Merck Patent GmbH

  公开号：EP2626072A1

  公开（公告）日：2013-08-14

  The present invention relates to piperidine and piperazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

  本发明涉及根据式（Ia）、（Ib）和（II）作为自旋素抑制剂的哌啶和哌嗪衍生物，以及将此类化合物用于治疗和/或预防生理和/或病理生理状况，这些状况是由溶血磷脂酸水平升高和/或自旋素活化引起、介导和/或传播的，尤其是不同的癌症。
• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US10434182B2

  公开（公告）日：2019-10-08

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

  本发明公开了一种八臂聚乙二醇（PEG）衍生物（式 I）、其生产方法及其改性生物相关物质。其中，一个四价基团 U 与四个三价基团 Ec 形成一个高度对称的八价基团 CORE0；Lc 将八价基团连接到八条具有多分散性或单分散性且聚合度为 n1 至 n8 的 PEG 链上；一条 PEG 链的末端与至少一个官能团 F 连接（k≥1）；所述 PEG 链和 F 之间可以直接连接（g=0），也可以通过连接基团 L0 与末端支化基团 G 间接连接（g=1）；后者提供了更多的反应位点，可以结合更多的药物分子，增加药物负载量。八臂聚乙二醇衍生物具有中心对称或近似中心对称结构，因此在大规模生产中可以更精确地控制分子量，产品的分子量分布也更窄。因此，改性生物相关物质的性能更均匀、更可控。