2-(5,6-di(pyridin-2-yl)-1,2,4-triazin-3-yl)-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(5,6-di(pyridin-2-yl)-1,2,4-triazin-3-yl)-1H-indole
• 英文别名: 2-(5,6-dipyridin-2-yl-1,2,4-triazin-3-yl)-1H-indole
• 化学式: C₂₁H₁₄N₆
• 分子量: 350.382
• InChiKey: GNOKVRIDQVGVHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吲哚-2-羧酸 在 hydrazine hydrate 、 硫酸 、 ammonium acetate 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 0.91h， 生成 2-(5,6-di(pyridin-2-yl)-1,2,4-triazin-3-yl)-1H-indole
  参考文献：
  名称：

  Design and Synthesis of New Hybrid Triazine-Indole Derivatives as Potential Antimicrobial Agents against Hospital Resistant Strains

  摘要：

  A new series of antimicrobial [2-(5,6-diary1-1,2,4-triazin-3-y1)-1H-indole] have been synthesized via microwave technology. The synthesized compounds were found to be potent against various clinical isolates of Gram-positive and Gram-negative bacteria as well as hospital resistant strains, MRSA and MSSA when compared to the drugs Cephtriaxone, Gentamycin and Levofloxacin.

  DOI：

  10.3987/com-13-12825

文献信息

• Design and Synthesis of New Hybrid Triazine-Indole Derivatives as Potential Antimicrobial Agents against Hospital Resistant Strains
  作者：Raed Al-Qawasmeh、Monther A. Khanfar、Mohamad H. Semreen、Raed Abu Odeh、Taleb H. Al-Tel

  DOI：10.3987/com-13-12825

  日期：——

  A new series of antimicrobial [2-(5,6-diary1-1,2,4-triazin-3-y1)-1H-indole] have been synthesized via microwave technology. The synthesized compounds were found to be potent against various clinical isolates of Gram-positive and Gram-negative bacteria as well as hospital resistant strains, MRSA and MSSA when compared to the drugs Cephtriaxone, Gentamycin and Levofloxacin.