O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactose
• 英文别名: Glc(b1-2)[Xyl(b1-3)]Glc(b1-4)b-Gal；(2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-2-[(2R,3R,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₂₃H₄₀O₂₀
• 分子量: 636.559
• InChiKey: DPSWBCAAYVEQQC-PVWXGCHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.9
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  328
• 氢给体数：
  13
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  番茄碱 在 tomatinase 作用下， 生成 番茄碱 、 O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-β-D-galactose 、 O-β-D-glucopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-O-β-D-glucopyranosyl-(1->4)-α-D-galactose
  参考文献：
  名称：

  茄果糖生物碱α-番茄碱中糖四糖的酶解

  摘要：

  支链四糖，O-β-d-吡喃葡萄糖基-（1-> 2）-O- [β-d-吡喃吡喃糖基-（1-> 3）]-O-β-d-吡喃吡喃糖基-（1-- > 4）-d-半乳糖（lycotetraose）是许多生物学上有趣的天然产物的关键组成部分。本文描述了从容易获得的茄属糖生物碱α-番茄碱方便地酶促制备四糖的酶。该制剂利用了来自植物病原体镰孢镰刀菌f的重组内切糖苷酶，番茄素酶。sp。lycopersici。

  DOI：

  10.1016/j.carres.2004.07.004

文献信息

• LIPID MEMBRANE STRUCTURE FOR siRNA INTRACELLULAR DELIVERY
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20170273905A1

  公开（公告）日：2017-09-28

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R 1 and R 2 represent CH 3 —(CH 2 ) n —CH═CH—CH 2 —CH═CH—(CH 2 ) m —, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R 3 and R 4 represent a C 1-4 alkyl group or a C 2-4 alkenyl group.

  一种脂质膜结构，其中包含一种siRNA并含有一种化合物(I)作为脂质成分（其中R1和R2代表CH3-（CH2）n-CH═CH-CH2-CH═CH-（CH2）m-，n表示3至5的整数，m表示6至10的整数，p表示2至7的整数，R3和R4代表C1-4烷基或C2-4烯基）。
• Lipid membrane structure for intracellular delivery of siRNA
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US10182987B2

  公开（公告）日：2019-01-22

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R1 and R2 represent CH3—(CH2)n—CH═CH—CH2—CH═CH—(CH2)m—, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R3 and R4 represent a C1-4 alkyl group or a C2-4 alkenyl group.

  一种脂质膜结构，在其内部封装 siRNA，并含有式 (I) 的脂质化合物作为脂质成分（R1 和 R2 代表 CH3-(CH2)n-CH═CH-CH2-CH═CH-(CH2)m-，n 代表 3 至 5 的整数，m 代表 6 至 10 的整数，p 代表 2 至 7 的整数，R3 和 R4 代表 C1-4 烷基或 C2-4 烯基）。
• LIPID MEMBRANE STRUCTURE HAVING INTRANUCLEAR MIGRATING PROPERTY
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20150202154A1

  公开（公告）日：2015-07-23

  A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.
• Enzymatic liberation of lycotetraose from the Solanum glycoalkaloid α-tomatine
  作者：Katherine Woods、Chris J. Hamilton、Robert A. Field

  DOI：10.1016/j.carres.2004.07.004

  日期：2004.9

  tetrasaccharide, O-beta-d-glucopyranosyl-(1-->2)-O-[beta-d-xylopyranosyl-(1-->3)]-O-beta-d-glucopyranosyl-(1-->4)-d-galactose (lycotetraose) is a key constituent of many biologically interesting natural products. Described herein is a convenient enzymatic preparation of lycotetraose from the readily available Solanum glycoalkaloid alpha-tomatine. The preparation makes use of the recombinant endo-glycosidase

  支链四糖，O-β-d-吡喃葡萄糖基-（1-> 2）-O- [β-d-吡喃吡喃糖基-（1-> 3）]-O-β-d-吡喃吡喃糖基-（1-- > 4）-d-半乳糖（lycotetraose）是许多生物学上有趣的天然产物的关键组成部分。本文描述了从容易获得的茄属糖生物碱α-番茄碱方便地酶促制备四糖的酶。该制剂利用了来自植物病原体镰孢镰刀菌f的重组内切糖苷酶，番茄素酶。sp。lycopersici。