(2R,3S)-dihydrokaempferol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (2R,3S)-dihydrokaempferol
• 英文别名: dihydrokaempferol；epiaromadendrin；(2R,3S)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
• 化学式: C₁₅H₁₂O₆
• 分子量: 288.257
• InChiKey: PADQINQHPQKXNL-HUUCEWRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (+)-Naringenin 在 iron(II) sulfate 苯磺酰胺 、 recombinant Arabidopsis thaliana flavonol synthase 、 catalase 作用下， 以 various solvent(s) 为溶剂， 反应 3.0h， 生成 德国春黄菊油 、 山奈酚 、 (2S,3S)-3,40,5,7-tetrahydroxyflavanone 、 (2R,3S)-dihydrokaempferol
  参考文献：
  名称：

  In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana

  摘要：

  cDNA corresponding to a flavonol synthase gene from Arabidopsis thaliana was cloned and expressed in Escherichia coli. The recombinant protein was purified to near-homogeneity and the catalytic properties of the enzyme were studied in vitro. Together with kaempferol and apigenin the recombinant protein synthesised the (2R,3S)-cis- and (2S,3S)-trans-isomers of dihydrokaempferol from the (2S)- and (2R)-isomers of naringenin, respectively. Flavanones and dihydroflavanols differing in degree of A- or B-ring hydroxylation were also accepted as substrates. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(02)00155-3

文献信息

• In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana
  作者：A Prescott

  DOI：10.1016/s0031-9422(02)00155-3

  日期：2002.7

  cDNA corresponding to a flavonol synthase gene from Arabidopsis thaliana was cloned and expressed in Escherichia coli. The recombinant protein was purified to near-homogeneity and the catalytic properties of the enzyme were studied in vitro. Together with kaempferol and apigenin the recombinant protein synthesised the (2R,3S)-cis- and (2S,3S)-trans-isomers of dihydrokaempferol from the (2S)- and (2R)-isomers of naringenin, respectively. Flavanones and dihydroflavanols differing in degree of A- or B-ring hydroxylation were also accepted as substrates. (C) 2002 Elsevier Science Ltd. All rights reserved.