N,N'-di-α-D-mannopyranosyl 1,4-butanediamine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N,N'-di-α-D-mannopyranosyl 1,4-butanediamine
• 英文别名: N,N'-di-(α-D-mannopyranosyl)-1,4-diaminobutane；(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-[4-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]butylamino]oxane-3,4,5-triol
• 化学式: C₁₆H₃₂N₂O₁₀
• 分子量: 412.437
• InChiKey: TVBWHGVMDKQHJJ-HVRGLFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  204
• 氢给体数：
  10
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  甘露糖 、 四亚甲基二胺 以 甲醇 为溶剂， 以53%的产率得到N,N'-di-α-D-mannopyranosyl 1,4-butanediamine
  参考文献：
  名称：

  一锅法合成多价甘露糖单糖和二糖阵列

  摘要：

  描述了一锅合成的多价甘露糖单糖和二糖阵列，其潜在用途可作为抗肠道细菌感染的抗感染剂。

  DOI：

  10.1016/s0040-4039(02)01855-5

文献信息

• One-pot synthesis of multivalent arrays of mannose mono- and disaccharides
  作者：Wayne Hayes、Helen M.I Osborn、Sadie D Osborne、Robert A Rastall、Barbara Romagnoli

  DOI：10.1016/j.tet.2003.08.011

  日期：2003.9

  The synthesis of a selection of multivalent arrays of mannose mono- and disaccharides, that are of potential use as anti-infective agents against enterobacteria infections, is described.

  描述了多种甘露糖单糖和二糖多价阵列的合成，其可能用作抗肠杆菌感染的抗感染剂。
• Synthesis and AFM studies of lectin–carbohydrate self-assemblies
  作者：Nidhi Gour、Sandeep Verma

  DOI：10.1016/j.tet.2008.05.055

  日期：2008.7

  Lectins are carbohydrate-binding proteins found in plants, viruses, bacteria, and animal cells having the ability to distinguish complex carbohydrate structures on cell surfaces. The ubiquity of lectin-carbohydrate interactions support the notion of a glycocode, which is related to highly specific recognition of carbohydrate display expressed on different cell surfaces of normal and diseased origin. The importance of these interactions in cell biology and medicine has been realized with the -applications ranging from blood typing to clinical diagnostics. This paper reports synthesis of some symmetrical carbohydrate derivatives, their interaction with lectin Concanavalin A and ultrastructural force microscopic studies of the complex formation. Preliminary efforts have been made to construct possible models to explain the nature of interaction within these assemblies. (c) 2008 Elsevier Ltd. All rights reserved.