3,6,9,12,15-pentaoxaheptadec-16-en-1-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6,9,12,15-pentaoxaheptadec-16-en-1-ol
• 英文别名: 2-[2-[2-[2-(2-Ethenoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
• 化学式: C₁₂H₂₄O₆
• 分子量: 264.319
• InChiKey: OYPQPQHDNYNAEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  18
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-2-氧代-4-苯基-3-丁烯酸 、 3,6,9,12,15-pentaoxaheptadec-16-en-1-ol 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以36%的产率得到2-oxo-4-phenyl-but-3-enoic acid 2-(2-{2-[2-(2-vinyloxy-ethoxy)ethoxy]ethoxy}ethoxy)ethyl ester
  参考文献：
  名称：

  Construction of dihydropyran-bridged macrocycles by inverse-electron-demand Diels–Alder reaction

  摘要：

  A variety of dihydropyran-bridged macrocyclic structures were constructed by the inverse-electron-demand Diels Alder reaction of 2-oxo-4-aryl-but-3-enoates. Controlling of the tether length and the position of the activating substituent in the substrates would guide the reaction to the formation of four different types of polycyclic frames, namely bicyclic [n.3.1], bicyclic [n.2.2], tricyclic [n.3.1.1], and tricyclic [n.2.2.2] macrocycles. The intermolecular/intramolecular selectivity of the Diels Alder reaction was virtually governed by the tether length. The reactions were carried out rapidly under mild conditions, and offered a practical method for creating bridged polycyclic structures with large rings from acyclic precursors. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.10.101
• 作为产物：
  描述：

  溴代-六聚乙二醇 在 水 、 potassium carbonate 作用下， 以 aq. phosphate buffer 为溶剂， 反应 0.58h， 以90%的产率得到六甘醇
  参考文献：
  名称：

  氨基聚苯乙烯负载的六甘醇桥接离子液体作为水介导的亲核羟基化的高效非均相催化剂†

  摘要：

  我们报告了一种基于氨基苯乙烯与带有六甘醇部分的 1-乙烯基咪唑离子液体的共聚制备氨基聚苯乙烯负载的六甘醇桥接离子液体 (APS-HEGBIL) 的简单且环保的方法及其表征通过几种分析技术。发现所得的 APS-HEGBIL 催化剂在催化卤代烷的选择性亲核羟基化以在水中产生相应的醇方面非常有效，该醇充当溶剂和亲核氢氧化物源。该催化剂在十次循环后易于回收并保持其催化活性和稳定性，并具有优异的收率。该催化剂的主要特性是它在反应过程中显着提高了水的亲核性，并促进了极性和碱敏感的卤代烷反应物以优异的收率快速转化为醇。离子液体和聚合物材料的结合提供了准均相催化剂，这些催化剂通过简单的过滤回收，并为进行催化过程提供了环境友好的手段。

  DOI：

  10.1039/c9ra00590k

文献信息

• New polymer materials for contact lens applications
  申请人：CIS Pharma AG

  公开号：US20200283560A1

  公开（公告）日：2020-09-10

  The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or more not-functionalized side chain-linked amino acids, (c) one or more functionalized side chain-linked amino acids, (d) a free radical initiator and, optionally, (e) a chain-transfer-agent. It also relates to block copolymers comprising the same monomers. The invention also encompasses silicone hydrogel contact lenses coated with or comprising the latter copolymers and block copolymers as well methods for introducing the copolymers and block copolymers into silicone hydrogel contact lenses.

  本发明涉及由聚合混合物制成的共聚物，所述聚合混合物包括（a）一种或多种可聚合单体，该单体被表征为至少具有一个乙烯基团且不含氨基酸残基，（b）一种或多种未功能化的侧链连接的氨基酸，（c）一种或多种功能化的侧链连接的氨基酸，（d）自由基引发剂，以及可选地，（e）链转移剂。还涉及包含相同单体的嵌段共聚物。该发明还涵盖涂有或包含后述共聚物和嵌段共聚物的硅水凝胶隐形眼镜，以及将这些共聚物和嵌段共聚物引入硅水凝胶隐形眼镜的方法。
• MONOMERS AND POLYMERS DERIVED FROM NATURAL PHENOLS
  申请人：CHISHOLM Bret Ja

  公开号：US20160023980A1

  公开（公告）日：2016-01-28

  Monomers, polymers and copolymers are provided that incorporate at least one naturally occurring phenolic compound, such as a plant phenol, as well as methods for producing the monomers and polymers. Plant phenols possessing a reactive group in addition to the phenolic group, such as a double bond, aldehyde, ester, alcohol or carboxylic acid, are particularly useful. Plant phenols can be isolated from a plant material, or chemically or enzymatically synthesized.

  提供了包含至少一种天然酚类化合物（如植物酚）的单体、聚合物和共聚物，以及制备这些单体和聚合物的方法。除酚基外，具有反应性基团（如双键、醛基、酯基、醇基或羧基）的植物酚尤其有用。植物酚可以从植物材料中分离出来，也可以通过化学或酶促合成。
• (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD

  公开号：US20180118658A1

  公开（公告）日：2018-05-03

  The present invention provides a (meth)acrylate manufacturing method characterized in that when manufacturing a (meth) acrylate by an ester exchange reaction between an alcohol and a monofunctional (meth)acrylate using catalyst A and catalyst B together, contact treatment of the ester exchange reaction product with adsorbent C is performed. Catalyst A: One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure and salts or complexes thereof, amidine and salts or complexes thereof, compounds with a pyridine ring and salts or complexes thereof, phosphines and salts or complexes thereof, and compounds with a tertiary diamine structure and salts or complexes thereof. Catalyst B: One or more kinds of compounds selected from a group consisting of compounds comprising zinc. Adsorbent C: One or more kinds of compounds selected from a group consisting of oxides and hydroxides comprising at least one of magnesium, aluminum and silicon.

  本发明提供了一种（甲基）丙烯酸酯制备方法，其特征在于通过在使用催化剂A和催化剂B一起进行醇和单官能基（甲基）丙烯酸酯之间的酯交换反应制备（甲基）丙烯酸酯时，对酯交换反应产物进行与吸附剂C的接触处理。催化剂A：从含有氮杂双环结构的环状三级胺及其盐或络合物、胺嘧啶及其盐或络合物、含有吡啶环的化合物及其盐或络合物、膦及其盐或络合物、以及含有三级二胺结构的化合物及其盐或络合物中选择的一种或多种化合物。催化剂B：从含锌化合物中选择的一种或多种化合物。吸附剂C：从含有镁、铝和硅中至少一种的氧化物和氢氧化物中选择的一种或多种化合物。
• METHOD FOR PRODUCING (METH)ACRYLATE
  申请人：TOAGOSEI CO., LTD.

  公开号：US20180105483A1

  公开（公告）日：2018-04-19

  A method for producing a (meth) acrylate comprises transesterification reaction of an alcohol and a monofunctional (meth) acrylate with catalysts in combination being cyclic tertiary amines having an azabicyclo structure and compounds containing zinc, separating a solid that contains the catalysts from a reaction product containing a (meth) acrylate, and producing a (meth) acrylate by transesterification reaction of an alcohol and a monofunctional (meth) acrylate, while using the recovered solid catalyst.

  生产（甲基）丙烯酸酯的方法包括使用具有氮杂双环结构的环状三级胺和含锌化合物作为催化剂，将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，从含有催化剂的固体中分离出含有（甲基）丙烯酸酯的反应产物，然后通过将醇和单官能团（甲基）丙烯酸酯进行酯交换反应，并使用回收的固体催化剂来生产（甲基）丙烯酸酯。
• Biocompatible polymers and co-polymers, and uses thereof
  申请人：Hitz Hans

  公开号：US20090232871A1

  公开（公告）日：2009-09-17

  The invention relates to highly biocompatible or biophilic un-cross-linked or cross-linked polymers comprising one or more side-chain active acrylic amino acids of formula I wherein: X is —NH(CH 2 ) 4 —, —O—C 6 H 4 —CH 2 —, —OCH 2 —, —O—CH(CH 3 )—, —S—CH 2 —, —O-proline, and R is H or CH 3 ; and wherein the polymer further includes a free radical initiator and, optionally, a cross-linking agent having a plurality of polymerizable ethylenically unsaturated groups. The invention further concerns various highly biocompatible, cross-linked co-polymers comprising one or more monomers of formula I, and one or more other polymerizable monomers. Uses of such polymers and co-polymers for the production of contact lenses, intraocular lenses, implants, wound healing slabs, additives for food and cosmetics, conductive plastics, spinnable fibers, and the like are disclosed.

  本发明涉及高生物相容性或亲生性的未交联或交联聚合物，其包括一个或多个侧链活性丙烯酸氨基酸（公式I），其中：X为—NH（CH2）4—，—O—C6H4—CH2—，—OCH2—，—O—CH（CH3）—，—S—CH2—，—O-脯氨酸，R为H或CH3；聚合物进一步包括自由基引发剂和可选的具有多个可聚合乙烯基不饱和基团的交联剂。本发明还涉及各种高生物相容性的交联共聚物，其中包括一个或多个公式I的单体和一个或多个其他可聚合单体。本发明还揭示了这些聚合物和共聚物的用途，用于生产隐形眼镜、人工晶体、植入物、伤口愈合垫、食品和化妆品添加剂、导电塑料、可旋转纤维等。