2-(pivaloyloxymethyl)-4-chloromethylthiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(pivaloyloxymethyl)-4-chloromethylthiazole
• 英文别名: [4-(Chloromethyl)-1,3-thiazol-2-yl]methyl 2,2-dimethylpropanoate
• 化学式: C₁₀H₁₄ClNO₂S
• 分子量: 247.746
• InChiKey: FQTBREQEPQLGEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-二氯丙酮 、 2-氨基-2-硫氧乙基特戊酸酯 以 乙醇 为溶剂， 生成 (4-(chloromethyl)thiazol-2-yl)methanol 、 2-(pivaloyloxymethyl)-4-chloromethylthiazole
  参考文献：
  名称：

  [EN] TRANS-9,10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHOS OF MAKING THE SAME
  [FR] TRANS-9,10-DEHYDROEPOTHILONES C ET D, LEURS ANALOGUES ET LEURS PROCEDES DE PRODUCTION

  摘要：

  公开号：

  WO2004043954A3

文献信息

• Trans-9,10-dehydroepothilone C and D, analogs thereof and methods of making the same
  申请人：——

  公开号：US20040152708A1

  公开（公告）日：2004-08-05

  The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

  本发明提供了基于trans-9,10-dehydroepothilone C和trans-9,10-dehydroepothilone D的新衍生物化合物、组合物和方法，用于体外抑制细胞过度增殖和/或稳定微管，并用于体内治疗过度增殖性疾病。本发明还揭示了制备这些化合物的方法。
• TRANS-9,10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHODS OF MAKING THE SAME
  申请人：Li Yong

  公开号：US20090186927A1

  公开（公告）日：2009-07-23

  The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

  本发明提供了基于新的trans-9,10-dehydroepothilone C和trans-9,10-dehydroepothilone D衍生物化合物、组合物和方法，在体外抑制细胞过度增殖和/或稳定微管，并在体内治疗过度增殖性疾病。还揭示了制备这些化合物的方法。
• Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same
  申请人：Kosan Biosciences Incorporated

  公开号：EP2135867A1

  公开（公告）日：2009-12-23

  The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

  本发明提供了新的反式-9,10-脱氢埃坡霉素 C 和反式-9,10-脱氢埃坡霉素 D 衍生物化合物、组合物以及体外抑制细胞过度增殖和/或稳定微管和体内治疗过度增殖性疾病的方法。还公开了制造这些化合物的方法。
• TRANS-9, 10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHODS OF MAKING THE SAME
  申请人：Kosan Biosciences Incorporated

  公开号：EP2135868A1

  公开（公告）日：2009-12-23

  The present invention provides a method of making trans-9,10-dehydroepothilones, comprising converting a 9-oxo-epothilone into the trans-9,10-dehydroepothilone.

  本发明提供了一种制造反式-9,10-脱氢埃坡霉素酮的方法，包括将 9-氧代埃坡霉素酮转化为反式-9,10-脱氢埃坡霉素酮。
• TRANS-9,10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHOS OF MAKING THE SAME
  申请人：Kosan Biosciences, Inc.

  公开号：EP1562941B1

  公开（公告）日：2009-12-23