N-hexanoyl-D-neuraminic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-hexanoyl-D-neuraminic acid
• 英文别名: (2S,4S,5R,6R)-5-(hexanoylamino)-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• 化学式: C₁₅H₂₇NO₉
• 分子量: 365.381
• InChiKey: MFCJJLCCEASWOA-BTIXGSHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  177
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  N-hexanoyl glucosamine 在 sodium hydroxide 、 phosphate buffer 、 immobilised sialic acid aldolase 作用下， 以 水 为溶剂， 反应 236.0h， 生成 N-hexanoyl-D-neuraminic acid
  参考文献：
  名称：

  Biological Properties of N-Acyl and N-Haloacetyl Neuraminic Acids: Processing by Enzymes of Sialic Acid Metabolism, and Interaction with Influenza Virus

  摘要：

  Several unnatural N-acyl neuraminic acids (N-propionyl, N-hexanoyl, N-benzoyl, N-trifluoroacetyl, N-chloroacetyl, N-difluoroacetyl) were prepared enzymatically using immobilised sialic acid aldolase. N-Trifluoroacetyl- N-chloroacetyl- and N-difluoroacetyl neuraminic acids were shown to enhance up to 10-fold the rate of association of influenza virus A to a sialoglycolipid neomembrane by surface plasmon resonance, and were found to act as weak inhibitors (K-iapp 0.45-2.0 mM) of influenza virus neuraminidase. The N-propionyl, N-chloroacetyl- and N-difluoroacetyl neuraminic acids were found to be substrates for recombinant Escherichia coli CMP sialate synthase, to give the corresponding CMP-N-acyl-neuraminic acids. CMP-N-propionyl neuraminic acid was found not to be a substrate for CMP-N-acetyl neuraminic acid hydroxylase from pig submandibular gland. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00213-4

文献信息

• Methods for purifying sialic acid-specific antibodies and composition comprising affinity-purified antibodies
  申请人：The Regents of The University of California

  公开号：EP2261255A1

  公开（公告）日：2010-12-15

  The present invention relates to a method of purifying sialic acid-specific antibodies, comprising the steps of: (a) preparing antibodies to sialic acids; (b) contacting the antibodies from step (a) with a first solid phase to which a sialic having a side chain has been attached; and (c) contacting the antibodies that bound to the first solid phase with a second solid phase to which the sialic acid without the side chain has been attached.

  本发明涉及一种纯化硅烷酸特异性抗体的方法，包括以下步骤： (a) 制备硅烷酸抗体； (b) 将步骤(a)中的抗体与第一固相接触，第一固相上附有具有侧链的硅铝酸；以及 (c) 将与第一固相结合的抗体与第二固相接触，第二固相附有无侧链的半乳淀粉酸。
• Methods for detecting and analyzing n-glycolylneuraminic acid (Neu5Gc) specific antibodies in biological materials
  申请人：The Regents of The University of California

  公开号：EP2302390A1

  公开（公告）日：2011-03-30

  The present invention relates to a method of detecting anti-Neu5Gc specific antibodies in a biological material comprising the steps of: (a) determining the amount of anti-Neu5Ac antibodies present in the material using Neu5Ac as an antigen target; (b) determining the amount of anti-Neu5Gc antibodies present in the material using anti-Neu5Gc as an antigen target; and (c) subtracting the amount of anti-Neu5Ac antibodies from the amount of anti-Neu5Gc antibodies to determine the amount of anti-Neu5Gc specific antibodies.

  本发明涉及一种检测生物材料中抗 Neu5Gc 特异性抗体的方法，包括以下步骤： (a) 以 Neu5Ac 为抗原靶标，确定材料中存在的抗 Neu5Ac 抗体的量； (b) 以抗 Neu5Gc 为抗原目标，确定材料中存在的抗 Neu5Gc 抗体的数量；以及 (c) 从抗 Neu5Gc 抗体的量中减去抗 Neu5Ac 抗体的量，以确定抗 Neu5Gc 特异性抗体的量。
• NEW DERIVATIVES OF NEURAMINIC ACID
  申请人：FIDIA S.p.A.

  公开号：EP0652887A1

  公开（公告）日：1995-05-17
• EP1651955A4
  申请人：——

  公开号：EP1651955A4

  公开（公告）日：2007-11-21
• METHODS FOR DETECTING AND ANALYZING N-GLYCOLYLNEURAMINIC ACID (NEU5GC) IN BIOLOGICAL MATERIALS
  申请人：The Regents of the University of California

  公开号：EP1651955A2

  公开（公告）日：2006-05-03